CHEN LAB

The complete sequence of the human genome provided quite a surprise to many by revealing that more than 98% of the transcriptional output represents non-protein coding RNAs (ncRNAs). In addition to housekeeping ncRNAs (rRNAs, tRNAs, etc.) and small RNAs (microRNAs, piRNAs, etc.), long noncoding RNAs (lncRNAs, >200nt) are emerging as a major class of eukaryotic transcripts with both reported and yet undiscovered roles in gene regulation... Our long-term goal is to discover new regulatory RNA species and to study their biogenesis and their mechanisms of action in mammalian cells. In the next five years, we are particularly interested in the following areas.

Also known as: Chen Lab SIBCB