SILICOFCM

According to the 2014 European Society of Cardiology Guidelines, cardiomyopathies are defined as structural andfunctional abnormalities of the ventricular myocardium that are unexplained by flow limiting coronary artery diseaseor abnormal loading conditions. There are four major classifications of cardiomyopathy: hypertrophic (HCM), dilated(DCM), restrictive (RCM), and arrhythmogenic right ventricular (ARVC)... Familial cardiomyopathies (FCM) are most commonly diagnosed, or progress of the disease is monitored, throughin vivo imaging, with either echocardiography or, increasingly, cardiac magnetic resonance imaging (MRI). Thetreatment of symptoms of FCM by established therapies could only in part improve the outcome, but novel therapiesneed to bedeveloped to affect the disease process and time course morefundamentally... SILICOFCM project will develop in silico computational cloud platform which will integrate from stopped-flowmolecular kinetic assays to magnetic resonance imaging of..