DDIP-PROTEOME.ORG

In this proposal we aim to close the gap, using both experimental and computational post-genome science, to study specific signalling pathways in a model organism (the fruit fly). Importantly, we already have the necessary methods in place to do this, bringing together UK experts in proteomics (both experimental and computational) with fly genomics and signalling experts to tackle this challenge. This includes state-of-the-art bioinformatics tools from groups who lead the way in the annotation of genome sequences and predicting protein function. Importantly, they are now able to consider the "unknowns" discussed above, such as different isoforms and their likely effects on interacting partner proteins... Funded by the BBSRC via a Strategic LoLa grant, we are conducting mass spectrometry driven analyses of the Drosophila proteome, integrated with bioinformatics and computational analyses to consider aspects of the interactome, alternate splicing and subcellular location of the..