Updated 16 days ago
The MuTHER project was established by the Wellcome Trust in 2007. Lymphocytes (LCLs and in some, fresh lymphocytes); subcutaneous fat; muscle and skin biopsies have been obtained from 856 twins (1/3 monozygotic, 2/3 dizygotic) from the well-characterised TwinsUK BioResource (link to TwinsUK). All samples have been genome-wide expression profiled (Illumina HT-12v3 Chip) and genome-wide association data (Illumina 610k or 1M chip) and methylation data (27k Illumina array in first instance) will also be available shortly...
The "MuTHER" ("Multiple Tissue Human Expression Resource") project is undertaking a coordinated program of analysis designed to understand the relationships between genome sequence variation, methylation status, mRNA expression and disease phenotypes.