Updated 77 days ago
Our group is working towards understanding the fundamental link between building block structure, mesoscopic structure, material properties and cell response of self assembling oligopeptides. This work brings a fundamental understanding of self-assembly and gelation processes that enables effective material design. Consequently we are able to direct the morphology (e.g.: fiber size, porosity, roughness) and mechanical properties (e.g.: modulus, viscosity) of our materials and tailor them to specific application needs. In particular we are elucidating the molecular drivers for ß-sheet forming peptide self-assembly across the length scales by synthesising short peptides with different amino acid sequences to systematically examine the effect of hydrophobicity, charge distribution and amino acid size/type. We are also fully characterising the structure and properties of the functional self-assembled networks and exploring their potential for therapeutic and clinical application... The..