THE COLUMBUS LAB - Key Persons
Professor Columbus is interested in understanding membrane biophysics to investigate the structure and dynamics of membrane proteins involved in bacterial pathogenesis.
Job Titles:
- Graduate Student and PostDoc
Jason research focused on the binding and uptake of Opa proteoliposomes into target cells expressing surface CEACAM receptors. He investigated which cellular uptake mechanisms Opa proteoliposomes engage as well as their intracellular processing following cell entry. Jason was particularly interested in exploring the potential of Opa proteoliposomes to target delivery to specific cell phenotypes.
Job Titles:
- Graduate Student and PostDoc
Job Titles:
- Principle Investigator ( PI )
- Professor
Professor Columbus is interested in understanding membrane biophysics to investigate the structure and dynamics of membrane proteins involved in bacterial pathogenesis.
Marissa's research aimed to determine the loop dynamics of Neisserial Opa proteins and to define the interaction surface of Opa-CEACAM binding using EPR. A low resolution Opa60 -CEACAM1 binding complex was generated using EPR data coupled with computational approaches (in collaboration with the Kasson laboratory).
Steven was a joint graduate student with Brant Isakson. His research focused on the molecular interactions between alpha-globin and eNOS and the physiological consequences of this interaction.
Tracy's research focused on the conformational dynamics of the membrane enzyme lipoprotein signal peptidase (LspA) using EPR. She also studied the physical properties of low-q bicelles, which are commonly used as membrane mimetics.