FIBROBLAST TRANSFECTION

Interspersed between the collagen fibers of dense connective tissue and the interstitial spaces in epithelial tissues are fibroblast cells. These cells are responsible for collagen production and serve to maintain the extracellular matrix and stroma in connective tissues. Fibroblasts do this by secreting compounds that serve as precursors to components of the extracellular matrix, which go on to form collagens, glycosaminoglycans, glycoproteins and reticular and elastic fibers. The extracellular matrix is important because its composition determines the physical properties of the connective tissue... Fibroblasts aid in maintaining the structure of connective tissues by the secretion of precursors of the extracellular matrix, which is primarily a mixture of fibers and the ground substance. Fibroblasts, along with related connective tissues help sculpt the majority of an organism and can migrate slowly over a substrate as individual cells. Although they often align in parallel when..