LISTER LAB

Our research aims to understand how readout of the information encoded in the DNA of plant and animal genomes can be influenced by the epigenome, the extent to which epigenomic modifications such as DNA methylation can be altered by the environment and in disease states, and to develop molecular tools for precision epigenome engineering... By modulating accessibility to the information encoded in the genome, chemical modifications of the DNA and associated proteins can affect gene activation and repression to execute distinct transcriptional programs and impart a stable state of transcriptional activity. We use advanced DNA sequencing, molecular, genetic and computational techniques to generate whole-genome high resolution maps of epigenetic modifications in a diverse range of complex multicellular organisms, including plants, humans, mice, and diverse vertebrates. Through these studies we aim to elucidate the mechanistic underpinnings of how the epigenome is established and..

Primary location: Crawley Australia