MANNINGLAB.ORG

Updated 70 days ago
  • ID: 7587344/111
We are a bioinformatics/genomics research group, based at the Salk Institute, near San Diego, California. We work on the genomics and evolution of protein kinases and phosphatases, and on more general questions of evolution of gene families, paritcularly in building accurate gene models for eukaryotes, and in orthology determination. We also work on selected questions in systems biolgy, particularly the evolution of pathways and of transcriptional regulatory networks in aging and proteostasis... Our kinase focus comes from Gerard's days at Sugen, a pioneering biotech company devoted to developing kinase inhibitors, and also from Eric Scheeff's work on protein kinase structures and evolution in Phil Bourne's lab at UCSD... In a paper lead by the Malek lab at Genentech, we've helped show how deleting a loop in the kinase domain is an oncogenic mechanism in EGFR, HER2 and BRAF kinases.
Also known as: Manning Lab
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Interest Score
1
HIT Score
0.56
Domain
manninglab.org

Actual
www.manninglab.org

IP
209.197.79.14

Status
OK

Category
Company, Other
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