MCCALL'S NURSERIES

for the treatment of these metabolic disorders. Regular exercise can. Several limitations of our study should be considered. Firstly, we recognize the limitations of the classification model: it is based on BTM values proposed as treatment targets, the cutoffs are arbitrarily chosen, the two markers analysed reflect mainly the function of osteoblasts and osteoclasts, but biochemical indicators of the osteocyte activity, important factors in the maintenance of skeletal integrity [135], are not included (currently these markers are used for research purposes). Therefore, the pathogenesis of bone metabolism is only partially represented by various subtypes, and there is no evidence at present that all patients with a particular subtype share the same metabolic defect(s). Although the proposed classification brings a conceptual shift in our understanding of the pathophysiology and clinical applications of bone turnover status, additional biochemical indicators of the complex multilayered..

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