LIGNOCELLULOSE - Key Persons
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- Department of Biological Sciences, University of Rhode Island
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- Department of Biochemistry and Molecular Biology, Pennsylvania State University
My CLSF studies are expected to reveal 3D electron density maps for structures of cellulose synthase complex (CSC) in resting and catalytic phases, from which we will learn how the structure of resting CSCs evolve when triggered to synthesize glucan chains for assembly into cellulose microfibrils. To do this work, we improve expression of membrane proteins, isolate enzyme from plant cell membranes, and reconstruct 3D structures from single particles obtained by conventional and dynamic TEM.
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- Associate Director
- Department of Crop Sciences, North Carolina State University
The Haigler lab will perform cryo-fracture deep-etch transmission electron microscopy in combination with immunolabeling of particular protein constituents to explore further the composition and function of the cellulose synthesizing complex. The aim is to understand the composition and operation of the cellulose synthesizing nanomachine from a bioengineering perspective.
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- Department of Biology, Pennsylvania State University
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- Director
- Biology Department, Pennsylvania State University
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- Department of Chemical Engineering, Pennsylvania State University
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- Department of Chemical Engineering, Pennsylvania State University
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- Biology and Soft Matter Division, Oak Ridge National Laboratory
Small-angle neutron scattering will be used to study the solution structure of the cellulose synthase complex (CSC) utilizing deuterium labeling of biomolecules, neutron diffraction and SANS approaches. Computational approaches will be focused on integrating neutron scattering and diffraction with simulation to improve the accuracy and efficiency of calculations giving new insights into the mechanisms of lignocellulose formation.
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- Department of Earth, Environmental and Resource Sciences, University of Texas at El Paso
James D. Kubicki has focused his research on using computational chemistry in tandem with experimental and analytical techniques to solve problems a wide variety of systems from silicate glasses, oxide nanoparticles, natural organic matter in soils, and bacterial extracellular polymers. Within CLSF, Kubicki has researched cellulose structure, plant cell wall component interactions and the generation/formation of cellulose.
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- Department of Molecular Physiology and Biological Physics, University of Virginia
Our group is interested in a molecular understanding of cellulose synthesis and membrane translocation. We use molecular and structural biology techniques to unravel how cellulose is synthesized and deposited outside the cell and how individual cellulose polymers can be organized into microfibrils.
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- Department of Chemistry, Massachusetts Institute of Technology
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- Department of Biochemistry, University of Cambridge
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- Department of Chemical Engineering, Pennsylvania State University
Our group has expertise in vibration spectroscopy and interfacial characterization. The Kim group is applying sum-frequency-generation (SFG) vibration spectroscopy to plant cell walls to study structure of crystalline cellulose and how interactions with other matrix polysaccharides influence the cellulose structure.
Computational prediction of secondary and three-dimensional structure of proteins in cellulose synthase complex. Molecular dynamics and Monte Carlo modeling of rosette and mechanisms of cellulose fiber production.
Job Titles:
- Department of Biochemistry & Molecular Biology, Penn State