CANCERRXGENE

As part of this collaboration, we are screening >1000 genetically characterised human cancer cell lines with a wide range of anti-cancer therapeutics. These compounds include cytotoxic chemotherapeutics as well as targeted therapeutics from commercial sources, academic collaborators, and from the biotech and pharmaceutical industries. The sensitivity patterns of the cell lines are correlated with extensive genomic data to identify genetic features that are predictive of sensitivity. This large collection of cell lines enables us to capture much of the genomic heterogeneity that underlies human cancer, and which appears to play a critical role in determining the variable response of patients to treatment with specific agents. Our drug sensitivity data and genetic correlations are freely available through our website as a resource to the academic and medical communities... The aim of our research is to improve cancer treatments by discovering therapeutic biomarkers that can be used to..

Primary location: Ann Arbor United States