CRAIK LAB

The neurotransmitter glutamate drives specific changes in the functioning of synaptic glutamate-gated ion channels. These changes modulate the strength of synaptic transmission, encode information, and allow for adaptive behaviors. We are developing and using small molecules to track the functional states of glutamate-gated ion channels at neuronal synapses... The SMDC offers an appropriate mix of industrial and academic expertise needed to advance research programs focused on developing new chemical probes with therapeutic potential. We collaborate with academic labs and pharmaceutical companies to discover compounds that bind to target proteins in vitro or in cells and can be used to modulate protein and cellular functions... As part of the Department of Pharmaceutical Chemistry in the UCSF School of Pharmacy, we enable innovative technologies for small molecule discovery to further the UCSF mission of advancing health worldwide.

Primary location: San Francisco United States