LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE

We conducted a review of published studies using the online databases Pubmed, African Journal Online and Bioline. Electronic searches using the terms: "malaria" "dhfr" "dhps" or "540" or "437" or "436" or "581" or 51 or 59 or 108 or 164 were carried out between October 2005 to February 2011. . In March 2016, we updated the review of the 540E and 581G mutations. To be included, studies had to include analysis of dhfr or dhps genes in P. falciparum isolates sampled from infected people living in a clearly identified geographical site in Africa... Google maps illustrating the distribution of dhfr and dhps genes associated with SP resistance in Africa.

Registration numbers: RC000330 (CH)