BMLS

Our group is focused on expanding the druggable proteome. We use two main approaches: (a) cell-based high throughput screening to discover novel chemicals as drug candidates and (b) drug repurposing, utilizing modern biotechnology methods to identify new targets of existing drugs. The methods used in our lab range from classic chemical synthesis to modern molecular biology, including organic synthesis, PROTAC technology, proteomics, various in vitro/cell-based assays, RNA-seq and gene manipulation... In this research focus, we study PKS and their catalytic potential. Our ultimate goal is to train these proteins to synthesize variations of the natural compounds, and, thus, to establish protein-mediated synthesis of polyketides as a tool in modern synthetic chemistry. For realization, we work on improved methods for manipulation and expression of PKS, and on establishing and refining structure-function relationships in PKS for efficient reaction control... The Institute was founded in..

Primary location: Frankfurt Am Main Germany