BMLS

In our lab we are focused in studying the molecular mechanisms of such guidance cues using a broad array of techniques including in vivo mouse models, tissue explants and cellular and biochemical assays. The Eph/ephrin system constitutes a striking example on how the nervous and vascular systems appear to use related developmental mechanisms... In this research focus, we study PKS and their catalytic potential. Our ultimate goal is to train these proteins to synthesize variations of the natural compounds, and, thus, to establish protein-mediated synthesis of polyketides as a tool in modern synthetic chemistry. For realization, we work on improved methods for manipulation and expression of PKS, and on establishing and refining structure-function relationships in PKS for efficient reaction control... The Institute was founded in 2009 as part of the Cluster of Excellence Frankfurt Macromolecular Complexes (CEF). We aim at understanding macromolecular complexes, in particular the..

Primary location: Frankfurt Am Main Germany