ABK BIOMEDICAL - Key Persons

Job Titles:

• Chairman of the Board
• Member of the ABK Biomedical Board of Directors
• Chairman of the ABK Biomedical Board of Directors

Dr. Berez is Chairman of the ABK Biomedical Board of Directors. He is the founder and CEO of Alembic, LLC, a medical device development company in Mountain View developing new devices for Interventional Neuroradiology. Cathera, Inc, an Alembic company, developed a suite of microcatheters optimized for intracranial navigation. Cathera was acquired by Medtronic in 2018. Palmera, Inc, an Alembic company, is developing new technologies for the minimally invasive treatment of stroke that have the potential to improve outcomes for patients that are currently treated, as well as widen the scope of patients that can benefit from therapy. At his previous company, Chestnut Medical, he led the development of the Pipeline Embolization Device for the treatment of complex intracranial aneurysms. In 2012, Pipeline was recognized as a top ten medical device innovation by the Cleveland Clinic. Today, it is being used to treat aneurysm patients all over the world and represents a $150MM annual franchise for Medtronic. Chestnut Medical was acquired by ev3 in 2009. Prior to that Dr. Berez worked at Smart Therapeutics where he helped develop the Neuroform and Wingspan intracranial stents, and Endovasix. Dr. Berez is currently an investor, advisor, and director to privately held medical device companies focused on capital-efficient medical device development. He is a graduate of the Georgetown University School of Medicine, where he received his MD degree. His postgraduate training was at UCSF/Mt. Zion in Internal Medicine, and Stanford University in Radiology and Neuroradiology.

Job Titles:

• Medical Device Executive
• Professional Engineer
• VP, Manufacturing, R & D and Engineering

Anthony Headley is an accomplished medical device executive with 25 years experience leading and building engineering, manufacturing, operations and R&D organizations for multi-national and start-up medical device companies including Symbiosis, Boston Scientific, Enpath Medical, Kimberly-Clark Healthcare, and Hollister Incorporated. He has held positions of increasing responsibility including Director, Sr. Director, Vice-President and General Manager during his career. He began his medical device career with Symbiosis Corporation (now Boston Scientific) where he quickly advanced into leadership positions in engineering and operations. He later relocated to Boston to lead the R&D stent development organization for Boston Scientific - Endoscopy where his team developed and introduced a number of market leading stent technologies. Before joining the ABK Biomedical Leadership Team, Anthony led the engineering organization for Hollister Incorporated where he managed a global team located in the US, Europe and Asia. Anthony is a licensed professional engineer and has been issued 26 US patents for medical device technologies during his career.

Job Titles:

• Chief Medical Officer

Dr. Aravind Arepally joined ABK in September 2022 as Chief Medical Officer. Dr. Arepally obtained a degree in mathematics and the Great Books program from Mercer University. He obtained his MD at Emory University School of Medicine and continued residency and chief residency in Radiology at Emory University Hospital. He did a Fellowship in Interventional Radiology at Johns Hopkins, joining the faculty in 2000. Dr. Arepally served as Associate Professor of Radiology & Surgery at Johns Hopkins Medical Institutes. In addition, he was Clinical Director for the Center for Bioengineering Innovation and Design, with a research focus on the development of embolics and cellular delivery for treating diabetes and obesity. In 2009, Dr. Arepally left Johns Hopkins and moved back to his native state of Georgia. While in Atlanta, he co-founded Surefire Medical, a company dedicated to developing catheters and embolization devices. In addition, Dr. Arepally has collaborated with research labs at Duke University and Johns Hopkins to develop novel embolic platforms, including advanced delivery catheter systems, embolic beads for targeted delivery, and new clinical applications such as Bariatric Embolization. Dr. Arepally is a practicing Interventional Radiologist at Piedmont Healthcare and Adjunct Professor of Radiology at Vanderbilt University School of Medicine with a research focus on translational research. His research has resulted in clinical translation with several "first in man" studies, FDA approvals, and the publication of multiple patents. Recently, he was Senior Director, R&D at Siemens Healthineers. He has authored more than 150 papers, books, and abstracts and has been a principal investigator or co-investigator on more than 15 grants (5 NIH). Dr. Arepally is the recipient of numerous national awards and grants for his research in MRI, device development, and embolization applications. He has also lectured nationally and internationally on minimally invasive therapies.

Job Titles:

• Director
• Member of the ABK Biomedical Board of Directors
• Director of Venture Capital at Medtronic

Carissa is the Director of Venture Capital at Medtronic. As part of the Medtronic's ventures team, she works closely with Medtronic leadership to identify new business needs and is responsible for sourcing, recommending, and managing new investment opportunities. Since joining Medtronic Ventures in 2016, she has led and managed investments that have resulted in multiple successful exits and she currently holds board director and observation seats at several Medtronic portfolio companies. Carissa is passionate about working with management teams and other investors to bring new innovations to market to improve patient outcomes. Before joining Medtronic Ventures, Carissa held various operating roles in strategy, business development, marketing, and research and development at Medtronic, Covidien, and Philips. She received her Ph.D. in Biomedical Engineering from Boston University and her MBA from Harvard Business School.

Job Titles:

• Life Sciences Executive
• VP of Clinical Development and Regulatory Affairs

David Dobrowski is an accomplished Life Sciences Executive and Enterprise Leader with over 25 years of pharmaceutical and medical device development experience. He has shepherded numerous new products through development and commercialization and has successfully executed more than a dozen FDA new product approvals, with a 100% success approval rate for 510k, NDA, BLA, and PMA submissions. David most recently worked at Merz where he started as Head of Regulatory Affairs and Product Safety in 2011. He was promoted to VP of R&D, responsible for Clinical Affairs & Operations, Scientific Affairs, Project Mgmt., NBD Integration, Product Safety, Medical Writing, and Regulatory. David was part of the Executive Leadership Team, managed a team of over 50 people, and was the recipient of CEO's Business Excellence President's Club award in 2015. Prior to joining Merz David shaped his career with roles of increasing responsibility at Salix Pharmaceuticals, UCB / Schwarz Biosciences, Wyeth, and Novartis. David will be responsible for the development/management of ABK's clinical programs and regulatory strategy/execution. He will also oversee the quality function.

Job Titles:

• Chief Business Officer

Gary Donofrio brings extensive marketing and commercialization experience to ABK, with over 25 years in the medical device field, including Sirtex Medical and Boston Scientific. Before joining the ABK Biomedical Leadership Team in 2017, Gary spent over seven years at Sirtex Medical, a global therapeutic oncology/medical device company, most recently as Senior Vice President, overseeing Marketing and Health Economics functions, and General Manager of the Latin America business unit. He started his career at Sirtex as Director of US marketing, where he managed all the marketing functions, including strategic planning, market development, conference management, KOL development, product commercialization, new business development (merger/partner assessment), and the sales force. He moved to Vice President, Marketing and then to Vice President, Americas Marketing and General Manager, Latin America, before becoming Senior Vice President. Gary also spent 17 years with Boston Scientific, Endoscopy, leading sales, marketing and commercialization functions. Gary has multiple achievement awards & accomplishments in sales, sales training, region sales management, global product management, global marketing management, e-marketing management, and market development management. > extensive marketing and commercialization experience with over 25 years in the medical device field.

Job Titles:

• Director
• Member of the ABK Biomedical Board of Directors

James joined Santé Ventures in 2009 and is an emergency medicine physician. Prior to joining Santé, James served in the Air Force and was Vice-Chair of Emergency Medicine at Wilford Hall Medical Center, an academic level-one trauma center. He completed two tours in Iraq as a Critical Care Transport Team Chief and Emergency Department Commander before separating honorably as a Major in 2008. James is an Oversight Committee member for the University of Michigan's Michigan Translational Research & Commercialization program, an early-stage granting body for life science companies. He is also a Mentor in the Coulter Program at Michigan and a Board Member of the Michigan Center for Integrative Research in Critical Care. James is board-certified in emergency medicine and completed his residency at Massachusetts General Hospital and Brigham and Women's Hospital. He earned his MD from the Harvard-MIT Program in Health Sciences and Technology (HST), his MBA from the University of Texas McCombs School of Business, and his BS in bioengineering from the University of Michigan. > executive and military veteran with an extensive background in the healthcare industry.

Job Titles:

• Director
• Managing Director of TM Capital Corp

James McLaren is a Managing Director of TM Capital Corp. a middle-market investment bank, where he is co-head of the firm's healthcare practice. He brings an extensive background in corporate finance and the healthcare industry to ABK Biomedical's Board. James joined TM Capital from Asante Partners, which he founded more than twenty years ago to provide quality strategic advice to middle-market healthcare companies. Previously, James had a twenty-year career advising corporate clients at Goldman, Sachs & Co. where he served as head of European Corporate Finance in London and of International Corporate Finance in New York, leading teams that executed significant global transactions. James is a director of CorVista Health, based in Toronto and Washington DC, that is developing a machine learning-based cardiac diagnostic platform to provide rapid, non-invasive tests to diagnose multiple cardiovascular conditions, including coronary artery disease, heart failure, and pulmonary hypertension. James is also an advisory board member of Radius Ventures, a New York-based firm focused on the healthcare industry, and was a director of Montreal-based RTP Pharma until its sale to Skye Pharma. James earned a BA with Honors in Economics from Oxford University, UK. > executive with an extensive background in corporate finance and the healthcare industry.

Job Titles:

• Director
• Member of the ABK Biomedical Board of Directors
• Partner

Ketan Patel is a Partner with F-Prime Capital and has worked in the healthcare sector as an investor, consultant, and physician. Prior to joining F-Prime Capital in 2007, Dr. Patel advised biopharmaceutical and medical device companies on brand strategy, clinical development plans, and business development activities in the corporate consulting division of Leerink Swann & Company. Dr. Patel served as a physician at the VA Boston Healthcare System and at Weill Cornell Medical Center-New York Presbyterian Hospital and Memorial-Sloan Kettering Cancer Center where he completed his internal medicine training Dr. Patel focuses on investing in therapeutics and medical device companies and has served on the Board of Directors of ABK Biomedical, Aclaris Therapeutics (NASDAQ:ACRS), Avalyn Pharma, Caplin Steriles, Comanche Biopharma, Eywa Pharma, Ivenix, Laurus Labs (NSE:LAURUSLABS), Medwell Ventures, Menlo Therapeutics (NASDAQ:MNLO), NextWave Pharmaceuticals (acquired by Pfizer), NFlection Therapeutics, Pediatrix Therapeutics, Rallybio (NASDAQ:RLYB), Vicept Therapeutics (acquired by Allergan). Dr. Patel is a graduate of Tufts University School of Medicine, where he received both his MD and MBA as part of that institution's Healthcare Management Program and was elected to the Alpha Omega Alpha Medical Honor Society. He completed his undergraduate studies in biology and economics with highest honors at Rutgers University..

Job Titles:

• Member of the ABK Biomedical Leadership Team
• Professional Mechanical Engineer
• VP Nuclear Strategy and Development

Marc Gregoire is an accomplished professional mechanical engineer with extensive experience in in the nuclear medical products sector. Throughout his over 25 year career, he has held several leadership positions directing the development, engineering and realization of radioactive medical devices and radiopharmaceuticals and manufacturing facilities in a complex regulated environment. Marc spent almost 20 years with Nordion Inc., working on radiopharmaceutical products and manufacturing facilities including Yttrium-90 and Indium-111 parenteral solutions, Y-90 implantable microspheres, Cobalt-60 external beam therapy machines and product delivery systems. During his tenure at Nordion, Marc also held prominent roles in package engineering, quality assurance, operations and strategic supply management. After Nordion, Marc spent four years developing a successful professional consulting practice working with multinational corporations, governments, and healthcare institutions as Director of Versant Solutions Inc. before joining ABK. As a member of the ABK Biomedical Leadership Team, Marc is responsible for nuclear strategy and development of ABK's microspheres irradia tion resourcing.

Job Titles:

• VP Nuclear Strategy and Development

> an accomplished professional mechanical engineer with extensive experience in the nuclear medical products sector.

Job Titles:

• Chief Executive Officer
• Executive
• Member of the ABK Biomedical Board of Directors
• President

Mike Mangano is the President and CEO of ABK Biomedical. Mike is an accomplished global executive leader with over 25 years' experience in the medical device industry. Over this time, he served as a member of senior leadership and executive committees and has a long history of success in building dynamic teams, leading organizational change, creating and shaping strategies, and executing programs leading directly to increased shareholder value. These accomplishments include his recent role as CEO of ReShape Medical, and his success in growing Sirtex Medical, an Interventional Oncology medical device manufacturer, from $34 million in revenue to over $130 million, during his six-year term as President of the Americas. Prior to his role at Sirtex Medical, Mike served 15 years at Boston Scientific, where he functioned in many key roles and most recently as Director of International Distribution Management. Mike brings pragmatic leadership to ABK with his vast experience in sales/marketing management, product development, strategic planning, international business, M&A, project management, and business model development. His experience and guidance will help take ABK Biomedical to the next level in delivering commercial excellence for our customers and the patients that will benefit from our innovative products.

Job Titles:

• Chief Financial Officer

Mike Tyson has extensive history and financial capabilities, including over 35 years' experience in public accounting and leadership positions with Allergan, Abbott Medical Optics (AMO) and six years with VC-backed AqueSys, Inc. Mike began his career working at Price Waterhouse Cooper, where he achieved his CPA designation. Mike then joined Allergan, where he spent 12 years, initially in their Corporate Accounting & SEC reporting group. He then moved overseas as Director of Finance in Puerto Rico, and finally lead Allergan's North American Accounting Operations. Mike joined ophthalmic medic device-maker AMO upon their spin-off from Allergan in 2002 and was appointed VP of Finance. There he set up the finance operation, headed finance for all their divisions, both domestic and international, and integrated key acquisitions. Mike was recruited by AqueSys, Inc. in 2010 to become VP of Finance & Operations. In October 2015 the company was acquired by Allergan in a highly successful, $300/$725 million exit. Most recently Mike has consulted with start-ups in the Orange County area, including ReShape Lifesciences and Fresca Medical. Mike is responsible for ABK's Finance, HR, and IT functions.

Job Titles:

• Director
• Member of the ABK Biomedical Board of Directors
• Physician - Scientist

Ricky Sharma is a physician-scientist leader of medical research at Varian, a Siemens Healthineers company. Professor Sharma's career vision is to develop personalized multidisciplinary care for every patient with cancer. Over the past two decades, Professor Sharma has led practice-changing international clinical trials and global initiatives to bring stakeholders together to improve combination treatments for patients with cancer.In addition to his role as Head of Clinical Affairs at Varian, he is a Clinical Oncologist and an Honorary Clinical Professor at University College London. Prior to joining Varian, Professor Sharma was the Chair of Radiation Oncology at University College London, UK. Professor Sharma has extensive experience of Board Membership of charities and the medical device industry. Professor Sharma graduated in Medicine from the University of Cambridge and obtained a PhD from the MRC Toxicology Unit, University of Leicester. He was an Associate Professor at the University of Oxford. In addition to his Fellowship of the Royal College of Physicans and Royal College of Radiologists, he was recently elected as a Senior Fellow of the Faculty of Medical Leadership and Management. > physician-scientist leader of medical research at Varian, a Seimens Healthineers company.