OROLAB

A leader in the biomedical revolution, Stanford Medicine has a long tradition of leadership in pioneering research, creative teaching protocols and effective clinical therapies... Stanford Health Care delivers the highest levels of care and compassion. SHC treats cancer, heart disease, brain disorders, primary care issues, and many more... How do tumors evolve to keep growing despite our best treatment efforts? Basal cell carcinomas (BCCs) are the most common human tumor, are driven by the hedgehog signaling pathway, and a model for the pathogenesis and treatment of other human tumors. We have shown that advanced BCCs frequently acquire resistance to Smoothened (SMO) inhibitors through both genetic and epigenetic tumor mechanisms, providing a unique opportunity to study human tumor and tumor environmental evolution in vitro, in animal models, and in patients through multi-dimensional genomic and proteomic approaches. We have identified several novel but common resistance pathways..

Primary location: Stanford United States