LUBIN LAB
Updated 160 days ago
Shelby Building Room 1175/1102 1825 University Blvd. Birmingham, AL 35294
Our research program focuses on neurons and synapses in the hippocampus, entorhinal cortex, and amygdala, brain regions that play an important role in learning and memory and in the development of several cognitive deficits in humans. We have found that memory-associated gene transcripts are dynamically regulated by DNA methylation and specific histone lysine methylation changes in the hippocampus during memory consolidation. Current work includes an assessment of DNA/Histone demethylating agents and viral/optogenetic tools to manipulate function of the epigenome that may be promising in the mitigation or disruption of cognitive disorders.