ZINC-NET

Given the fundamental functions of zinc in cell biology, it comes as no surprise that perturbations of the homeostatic mechanisms that regulate cellular Zn 2+ are involved in many diseases, including degenerative diseases, such neurodegeneration (Alzheimer disease, stroke), diabetes, cancer, and wound healing. The World Health Organization considers zinc deficiency as the 5th leading cause of morbidity and mortality in developing countries (11th worldwide). The clinical symptoms of severe zinc deficiency in humans include dermatitis, diarrhea, alopecia, re-current infections (pneumonia) and neurological disturbances. In children, it is also a cause for stunted growth, including stunted sexual maturation in boys.