GLYCOTECH.UGA.EDU

Hydroxy radical footprinting is being deployed using LC-MS and electron-transfer dissociation (ETD) fragmentation to examine the details of interaction interface residues down to the single amino acid residue level... NMR chemical shift perturbations identify different binding sites for CS and HS on the LINK-TSG6 module... A structural model of chemokine CCL5 oligomerization determined by a combination of NMR, MS, and SAXS approaches provides a framework for prediction of proteoglycan interactions and mechanism for proteoglycan-mediated oligomerization.

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