MDM2

Updated 45 days ago
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188-199.PubMed 7. Klemm KM, Moran CA
were treated with 0.1%, 0.2%, and 0.5% v/v ethanol for the invasion assay. (A) The top panel shows the average number of T47D cells per field that have invaded through the basement membrane-like Matrigel layer and into the lower Boyden chamber following the invasion assay. Diff-Quik staining of the lower chamber following the assay is shown below. The number of cells in the lower chamber is a direct measurement of cell invasion. (B) Invasion assay results are shown using MCF-7 (low invasive potential, top panel) and MDA-MB-231 (high invasive potential, bottom panel) breast cancer cells. (*p < 0.05, as compared to the control cells with no alcohol treatment). Alcohol increases breast cancer cell invasiveness by suppressing Nm23 expression To investigate the possibility that alcohol may increase cellular invasive ability by inhibiting the expression of specific metastasis suppressing genes, we determined the effects of alcohol on known metastasis suppressor genes. We examined the effects..
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