MCDONALD LAB

Image of the entire ovary by Yujun Chen - 11th place 2019 Nikon Small World competition... We use Drosophila border cells to study how groups of cells ("collectives") move inside the three-dimensional environment of tissues. We are interested in how cells migrate during development, e.g. during organ formation and tissue remodeling, and in diseases such as cancer, where it contributes to tumor invasion and metastasis... Stills from movie of live border cell migrationEgg chamber labeled for PVR (magenta) and PVF1 (green): guidance receptor and ligand, respectively, for border cellsDisorganized mutant border cellsMutant that causes border cell cluster to fall apartEgg chambers stained for nuclear lamin (R), E-cadherin (G), DAPI (B): image Yujun ChenImage by Yujun Chen, chosen for Science to.

Primary location: Manhattan United States