HOLASKA LAB

To address how emerin regulates gene expression, we are studying how emerin regulates the activity of a newly discovered transcription factor named Lmo7. Importantly, Lmo7 regulates the expression of critical muscle stem cell differentiation and is required for proper myogenic differentiation. We are also exploring how emerin regulates genomic architecture during myogenic differentiation. For these studies we are identifying the genomic regions that associate with emerin in muscle stem cells and how the association of these regions changes during myogenic differentiation. We are also characterizing the trans-factors that regulate chromatin repression and association of the genome with the nuclear envelope. Lastly, we are also examining the role of emerin and Lmo7 in regulating mesenchymal stem cell differentiation, since all the tissues affected in nuclear envelope-associated diseases are derived from the mesenchymal lineage... My lab studies how nuclear envelope proteins regulate..