PHARMACOLOGY - Key Persons
Job Titles:
- Assistant Professor / Research: Combination Cancer Therapy
- Assistant Professor, Pharmacology / Research Interests
The Palmer laboratory investigates combinations of cancer therapies: understanding the mechanisms of successful drug combinations, to inform the development of combinations with new cancer therapies. Our approach is a synthesis of experimental studies, computational analysis of clinical data, and mathematical modeling. I have a particular interest in the clinical implications of variation in drug response between patients and between cells (a consequence of inter-tumor and intra-tumor heterogeneity). Because heterogeneity is a universal feature of cancers and their responses to therapy, this research impacts our understanding of treatment success and failure across many forms of cancer and types of therapies. Our experimental focus is on curative combination therapies for aggressive lymphomas; many new therapies have been developed for these diseases, and we are taking a systematic approach to find optimal drug combinations for different patient subsets. The basic and translational research we are pursuing serves the practical goal of improving the design of drug combinations and the interpretation of clinical trials that test them.
Job Titles:
- Advisor
- Professor
- Professor, Pharmacology Professor, Radiation - Oncology Member, Lineberger Comprehensive Cancer Center / Research Interests
- Research
Research: Lipid modification, signal transduction, and protein function of Ras family oncogenes
Title of Dissertation: "Impact of subcellular localization on oncogenic functions of the RhoGEF Ect2 and on its Rho GTPase targets"
Title of Dissertation: "Tyrosine kinase modulation of trafficking and biological functions of the atypical Rho GTPase, Wrch-1"
Title of Dissertation: "The transforming Rho family GTPase, Wrch-1, regulates epithelial cell morphogenesis through modulating cell junctions and actin cytoskeletal dynamics"
Title of Dissertation: "Characterization of the small GTPase Rac3 in signaling and transformation"
Job Titles:
- Kenan Distinguished Professor Emeritus / Research: Signal Perception and the Regulation of Growth and Development
Job Titles:
- Assistant Professor / Earp Lab
Title of Dissertation: "Mechanisms that promote liberation of mitotic stress-induced death"
Job Titles:
- Research Associate, Principal Data Analyst
- Research Project Manager
Angie, originally from Lyon, France, earned her B.S. in Marine Biology from the University of West Florida, where she conducted bioremediation research under the guidance of Dr. Jim Spain. She then pursued an M.S. in Microbiology from North Carolina State University, contributing to research in Dr. Manuel Kleiner's lab, where she explored diet-intestinal microbiome interactions using metaproteomics. In 2021, Angie joined the UNC MAP Core (formerly the Proteomics Core) as a Research Associate. She specializes in comprehensive data analysis-including statistics, visualization, and pathway analysis-across a wide range of projects, such as global proteomics, metaproteomics, phosphoproteomics, PTM site mapping, protein characterization, and drug-pulldown studies.
Job Titles:
- Assistant Professor / McElligott Lab
Job Titles:
- Associate Professor, NCCU / Research: Molecular Targets Involved in the Transformation of Pancreatic Cancer
Job Titles:
- Research Associate
- Research Associate, Pharmacology & UNC Metabolomics and Proteomics ( MAP ) Core
Aurora graduated from Meredith College in 2012 with a B.S. in Chemistry and a minor in Mathematics. For a year, she worked as a Chemist at the System and Translational Sciences Center at RTI international in RTP, NC. As a Chemist, and under the guidance of Dr. Suraj Dhungana, she performed broad spectrum metabolomic analyses on tissues and biofluids. In 2021, Aurora earned her PhD in Chemistry from Duke University. Under the guidance of Professor Michael Fitzgerald, she applied and developed bioanalytical methods for mass spectrometry-based protein stability measurements. She joined UNC-Chapel Hill as a Post-doctoral Research Associate and was under the guidance of Professor Lee Graves and Dr. Laura Herring. Her post-doctoral work included the application of a kinase enrichment strategy (MIB/MS) to elucidate kinase drug targets, and the development of a thermal denaturation strategy for drug target deconvolution. In 2023, she transitioned into a Research Associate role at the MAP Core (formerly the Proteomics Core). At the MAP Core, Aurora helps with sample preparation and aids in maintaining and calibrating the Core's mass spectrometers.
Title of Dissertation: "Enhancing the function and delivery of chimeric antigen receptor T-cells: Implications for treatment of solid tumors"
Title of Dissertation: "Identification and characterization of kinase regulators in KEAP1/NPF2 signaling."
Job Titles:
- Advisor
- Boshamer Distinguished Professor
Title of Dissertation: "Regulation of alpha7 neuronal nicotinic acetylcholine receptors by extracellular divalent cations"
Job Titles:
- Advisor
- Associate Professor
Job Titles:
- Advisor
- Distinguished Professor
- Research
Title of Dissertation: "Development of next-generation G protein biosensors for deconvoluting the complexity of GPCR signaling"
Title of Dissertation: "Ligand discovery and functional characterization of MRGPRX family orphan GPCRs"
Title of MS Thesis: "Engineering and Biophysical analysis of alpha adrenergic receptor crystallography constructs"
Title of Dissertation: "Identification of biased kappa opioid receptor ligands for in vivo probing of specific signal transduction pathways?"
Title of Dissertation: "The cochaperone and ubiquitin ligase CHIP in protein quality control"
Job Titles:
- Administrative Support Specialist
Title of Dissertation: "Low dose vertical inhibition of ERK MAPK cascade for the treatment of KRAS-mutant cancer."
Title of Dissertation: "Development and application of a MYC degradation screen in KRAS-mutant pancreatic cancer."
Title of Dissertation: "Targeting the Ras-Ral effector pathway for cancer treatment"
Title of Dissertation: "The role and mechanism of fibroblast growth factor receptor 2 in cellular transformation"
Title of Dissertation: "Microbial signaling in intestinal ischemia/reperfusion injury response."
Title of Dissertation: ""Mechanisms of mu opioid receptor mediated protection from multiple models of acute injury"
Job Titles:
- Administrative Support Specialist
Job Titles:
- Assistant Professor / Der Lab
Job Titles:
- Advisor
- Professor
- Research
Title of Dissertation: "The role of metabotropic glutamate receptors and associated cell signaling pathways in the acute sedative-hypnotic effects of ethanol"
Job Titles:
- Research Technician / Sondek Lab
Crystal Pace received her B.S. in Chemistry from Meredith College and her Ph.D. in Bioanalytical Chemistry from North Carolina State University. Her doctoral research centered on developing a novel ionization source to enable the spatial analysis of metabolites, lipids, glycans, and proteins, shedding light on their associations with environmental exposures and tumor micro-environments. After graduate school, Crystal was a Senior Research Scientist at Metabolon where she led various analytical initiatives aimed at enhancing process efficiency and data quality for untargeted metabolomics and targeted lipidomic services. Crystal recently joined the MAP Core Team to assist in establishing a suite of metabolomic services to aid in uncovering critical insights into human health and disease.
Job Titles:
- Research Technician / Dohlman Lab
Job Titles:
- Assistant Professor
- Assistant Professor, Pharmacology Member, Lineberger Comprehensive Cancer Center / Research Interests
The Dominguez lab studies how gene expression is controlled by proteins that bind RNA. RNA binding proteins control the way RNAs are transcribed, spliced, polyadenylated, exported, degraded, and translated. Areas of research include:
Job Titles:
- Advisor
- Eshelman Distinguished Professor, School of Pharmacy
Title of Dissertation: "R4 and R12 subfamily RGS proteins-Structure, funtion, and emerging chemical biology"
Job Titles:
- Facilities Maintenance Technician
Job Titles:
- Advisor
- Assistant Professor
Job Titles:
- Student Events / Assistant
Job Titles:
- Assistant Professor
- Assistant Professor, Pharmacology Assistant Professor, Chemistry / Research Interests
Research in the Brunk laboratory focuses on developing computational methods that accelerate the clarity and utility of omics data in biomedical science. Our aim is understanding the link between genetic/molecular variation and phenotype, both in natural and engineered cellular systems. We approach these topics through the lens of computational biology, machine learning and advanced data integration. Thanks to the growing body of cancer omics data, our methods borrow strength across genomics, transcriptomics, ribosome profiling, proteomics, structural genomics, metabolomics and phenotype variability data.
Job Titles:
- Assistant Professor
- Research Specialist
- Research Technician
Job Titles:
- Assistant Professor, Ecuador
Title of Dissertation: "Cellular and molecular mechanisms underlying srGaP2 function during neuronal development"
Job Titles:
- Advisor
- Director of the UNC Bowles Center for Alcohol Studies
- Distinguished Professor
- Research
Title of Dissertation: "Microglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawal."
Job Titles:
- Advisor
- Professor
- Professor of Pharmacology & Former Kenan Distinguished Professor, Pharmacology Member, Lineberger Comprehensive Cancer Center / Research Interests
Title of Dissertation: "Determining the consequence of PTEN loss in BRAF-mutant melanoma treated with Dabrafenib and Trametinib."
Title of Dissertation: "Cerebral Cavernous Malformations is a disease of dysregulated expression of RhoA and Rap1 proteins"
Job Titles:
- Professor Emeritus / Research: Molecular Mechanisms of Membrane Transport
Job Titles:
- Lineberger Distinguished Professor & Director
Job Titles:
- Assistant Professor
- Research Associate
Job Titles:
- Advisor
- Sanford Steelman Distinguished Professor & Chair of the Department of Pharmacology Member, Lineberger Comprehensive Cancer Center / Research Interests
- Sanford Steelman Distinguished Professor and Chair of the Department
Title of Dissertation: "Structural mechanisms of G protein activation and suppression"
Title of Dissertation: "Activation of G protein signaling by a non-receptor exchange factor"
Research in the Dohlman Lab is centered on G proteins and G protein-coupled receptors (GPCRs). GPCRs are the target of many pharmaceuticals, hormones and neurotransmitters, as well as most environmental signals. Generally speaking, persistent stimulation of G proteins lead to desensitization. Familiar examples include desensitization to light, odors and chemical stimulants such as caffeine.
Title of M.S. Thesis: "Identifying genetic factors affecting anthracycline-induced cytotoxcity."
Job Titles:
- Advisor
- Associate Professor & Director of Graduate Studies, Pharmacology Member, Lineberger Comprehensive Cancer Center / Research Interests
- Associate Professor and Director of Graduate Studies
Long-term goals of the Calabrese laboratory are to determine the nuclear functions and molecular mechanisms of long noncoding RNAs (lncRNAs), and to develop methods to modulate lncRNA function for therapeutic gain. Projects in the lab include: mechanisms of RNA-mediated recruitment of Polycomb complexes to chromatin, mechanisms of gene silencing by Xist and Xist-like lncRNAs, mechanisms of lncRNA homeostasis with relation to gene control in cancer, discovery of novel regulatory RNAs, control of lncRNA regulatory function through cellular signaling pathways, and developing new methods to predict relationships between lncRNA sequence and regulatory function. We use a combination of genomics, genetics, molecular and cell biology, biochemistry, and computational biology to achieve our research objectives.
Motivated graduate students and post-doctoral fellows interested in joining the group are encouraged to contact Dr. Calabrese via email.
Job Titles:
- Assistant Professor / Calabrese Lab
Job Titles:
- DIstinguished Professor & Vice Chair for Research
Current Position: Senior Clinical Research Associate (Oncology), Covance
Job Titles:
- Research Specialist / Crews Lab
Job Titles:
- Assistant Professor, UNC - CH
Job Titles:
- Advisor
- Professor & Vice Chair of Research
Title of M.S. Thesis: "Identifying biomarkers of response to modified FOLFIRINOX regimens using patient derived xenograft mouse models of pancreatic ductal adenocarcinoma"
Job Titles:
- Assistant Professor
- Assistant Professor, Pharmacology Member, UNC Neuroscience Center / Research Interests
Job Titles:
- Administrative Support Specialist
Job Titles:
- Research Associate / Crews Lab
Job Titles:
- Research Specialist / Nicely Lab
Job Titles:
- Assistant Professor
- Assistant Professor, Pharmacology Member, Lineberger Comprehensive Cancer Center / Research Interests
Tumorigenesis reflects the emergence of lineages that no longer conform to the differentiation programs essential for organ development, maintenance, and regeneration. The Morris Lab strives to understand how cancer drivers initiate and maintain lineages that no longer "play by the rules" of evolutionarily dictated cell fate specification and hierarchical organization in order to identify, revert, and eliminate them.
Job Titles:
- Distinguished Professor
- Research
Job Titles:
- Director, Bowles Center for Alcohol Studies
- Distinguished Professor and Director, Bowles Center for Alcohol Studies
- Research
Research: Neurodegeneration & chronic drug-induced changes in brain signaling pathways
Research: Neurophysiological alterations underlying dysregulated emotional behavior
Research Interests
Mental Disease and Addiction
Neurodegeneration and chronic drug-induced changes in brain signaling pathways.
Stem Cells
Stem cells, which are found in specific brain regions and form new neurons, could be involved in the regeneration of the brain during recovery from addiction. Binge drinking reduces proliferation of neural progenitor cells in brain.
Gene Delivery
A third area of research involves the use of gene delivery to understand how alterations in genes alter brain function and behavior.
Job Titles:
- Advisor
- Professor
- Research
Title of Dissertation: "Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes"
Title of Dissertation: "Defining diverse mechanisms that regulate the activity of Dbl-family guanine nucleotide exchange factors"
Title of Dissertation: "Coordinating the activation of RhoA by diverse RhoGEFs: SmgGDS and G-alpha-q-responsive Dbl family guanine nucleotide exchange factors"
Job Titles:
- Assistant Professor
- Research Associate
- Research Technician
Job Titles:
- Advisor
- Assistant Professor
- Assistant Professor, Pharmacology Member, McAllister Heart Center / Research Interests
The Schisler Lab works on the integration of complex genomic-biologic data to elucidate risk relationships in both murine and human systems with a focus on cardiovascular disease and protein quality control mechanisms. My primary focus is to develop models to integrate datasets derived from clinical genomics, transcriptomics, and metabolomics allowing our lab to further interrogate gene and protein function in health and disease using molecular, cellular and biochemical approaches. The Schisler Lab is keenly interested in cellular regulatory mechanisms including post-translational regulation pathways, such as protein quality control, in both health in disease. E3 ligases are enzymes that modify substrate proteins via ubiquitination, the addition of a small ubiquitin protein, that can either alter protein function or target the substrate protein to the proteasome for degradation. Our research in this field initially focused on the role of the E3 ligases CHIP and MuRF1 in cardiovascular function. Recently we identified the first human causal mutation in CHIP that results in cerebellar ataxia and hypogonadism; as such, my laboratory expanded its ability to include neuro and neuro-endocrine approaches in our mouse and cell-based models to complement our cardiovascular research program.
In addition to animal and cell-based models of health and disease, the Schisler Lab utilizes clinically-derived datasets to model human disease and to complement work done in basic research models. Through the use and often combination of multiple ‘omic' platforms, we performed several important studies on human diseases including a study that identified specific genetic variation between Caucasian and African Americans that modifies sugar metabolism genes contributing to diabetes and increased cardiovascular risk. We continue to expand our translational-based research program into other inflammatory diseases such as hypertension and coronary artery disease. The Schisler Lab actively collaborates with colleagues in public heath to focus on extending translational research to at-risk populations where health disparities are prevalent and underrepresented in the literature.
Job Titles:
- Advisor
- Associate Professor
Title of Dissertation: "Determination of cross-species immune responses from outer membrane vesicle-based meningococcal vaccines to Neisseria gonorrhoeaee"
Title of Dissertation: "Mechanisms and consequences of Staphylococcus aureus Leukocidin AB-mediated activation of the host NLRP3 inflammasome"
Title of Dissertation: "The role of lytic transglycosylases LtgA and LtgD in innate immune recognition and pathogenesis of Neisseria gonorrhoeae."
Job Titles:
- Assistant
- Research Director
Job Titles:
- Professor & Jeffrey Houpt Distinguished Investigator
- Professor, Jeffrey Houpt Distinguished Investigator Department of Pharmacology and Neuroscience Center / Research Interests
Title of Dissertation: "Understanding mechanisms of Adeno-associated virus vector transduction through pharmacological and biological approaches"
Job Titles:
- Department Services Coordinator
Job Titles:
- Advisor
- Professor Emeritus / Research: Glial Cells in Brain Function
Title of Dissertation: "Stimulating glial Gq-coupled GPCR pathways blocks acute pain and itch"
Title of Dissertation: "Cellular, histological and behavioral changes in the pathogenesis of hydrocephalus in the Ro1 mouse model"
Title of Dissertation: "Expression of the Gi-coupled RASSL Ro1 in GFAP-positive cells: a novel model of hydrocephalus"
Title of Dissertation: "Role of the inward rectifying K+ channel, Kir4.1, in astrocyte physiology and neuronal excitability"
Job Titles:
- Associate Professor
- Associate Professor, Pharmacology / Research Interests
Pruitt lab research involves 3 broad areas. Interest in the first area (cancer epigenetics) stemmed from discoveries made during postdoctoral training assessing how tumor progression disrupts epigenetic mechanisms of control. The second area (Wnt pathway regulation) was the result of early screens as an Assistant Professor at LSU Health Sciences Center. We uncovered novel regulators of oncogenic Wnt signaling and published the first observation that epigenetic enzymes regulate a critical mediator of Wnt signaling (Dishevelled). The third project involves elucidating mechanisms of aromatase regulation which emerged from the obsession of early trainees in the lab with understanding mechanisms cancer-associated estrogen biosynthesis. Within the context of these three projects, I have mentored and guided multiple trainees at every level over the course of 17 years.
Job Titles:
- Associate Professor / Director, UNC Neuroscience Center / BRAIN Initiative NeuroTools Vector Core
- Associate Professor, Pharmacology Director, UNC Neuroscience Center / BRAIN Initiative NeuroTools Vector Core
Job Titles:
- Assistant Professor / Research: Autophagy, Pancreatic Cancer, Cancer Metabolism, RAS Oncogenes, Molecular Therapeutics
- Assistant Professor, Pharmacology Member, Lineberger Comprehensive Cancer Center / Research Interests
Job Titles:
- Advisor
- Distinguished Professor
- Research
Title of Dissertation: "Dissecting the role of kinase isoforms using new tools for activation and inactivation of kinases in vivo"
Job Titles:
- Assistant Professor
- Assistant Professor / Research: Alcohol Use Disorders
Job Titles:
- Associate Professor
- Director
- Associate Professor, Pharmacology Director, UNC Metabolomics and Proteomics ( MAP ) Core
- Research Associate Professor, Director
Laura is a North Carolina native and earned her BS in Biochemistry and BA in Chemistry from North Carolina State University. After a three-year stint in industry, she went back to North Carolina State University where she received her PhD in Biochemistry in 2015. She focused on mass spectrometry-based proteomics method optimization and application to study signal transduction pathways dysregulated in cancer in the labs of Drs. Michael Goshe and Jason Haugh. She joined UNC's Pharmacology Dept in 2015 and is the Director of the MAP Core. She has a strong interest in biomarker discovery, phosphoproteomics and chemoproteomics. She is primarily responsible for overseeing all administrative aspects of the core, facilitating and designing projects with collaborators, and leading proteomics/metabolomics initiatives. She assists in grant and manuscript writing, organizes campus-wide events (Mass Spectrometry Seminar Series), and teaches PHCO750: Methods in Proteomics.
Job Titles:
- Assistant Professor
- Assistant Professor / Research: Gut - Brain Mechanisms Underlying Substance Use Disorder
Job Titles:
- Advisor
- Director
- Professor
- Professor, Faculty Director
- Professor, Pharmacology Faculty Director, UNC METABOLOMICS and PROTEOMICS ( MAP ) CORE / Research Interests
Title of Dissertation: "Exploring the role of mitochondrial protease ClpP in apoptosis regulation of triple negative breast cancer cells."
Title of Dissertation: "Lyn regulates drug resistance mechanisms in chronic myelogenous leukemia"
Job Titles:
- Assistant Professor
- Assistant Professor, Pharmacology Member, Bowles Center for Alcohol Studies / Research Interests
The overriding goal of Dr. Coleman's work is to identify novel treatments for alcohol use disorders (AUD) and associated peripheral disease pathologies. Currently, this includes:
Job Titles:
- Advisor
- Professor
- Research
Title of Dissertation: "CIB1: A promising target in triple-negative breast cancer."
Title of Dissertation: "Regulation of cell survival by CIB1, a new modulator of 3-phosphoinositide-dependent protein kinase 1 (PDK1)"
Title of Dissertation: "Mechanisms and functions of glycoprotein VI-mediated Rap1 activation in platelets"
Job Titles:
- Research Associate / Crews Lab
Job Titles:
- Assistant Professor
- Assistant Professor, Pharmacology / Research Interests
Job Titles:
- Human Resources Consultant
Job Titles:
- Advisor
- Associate Professor
- Associate Professor, Pharmacology Member, Bowles Center for Alcohol Studies / Research Interests
Job Titles:
- Distinguished Professor
- Research
Job Titles:
- Advisor
- Professor
- Professor, Pharmacology Member, Lineberger Comprehensive Cancer Center / Research Interests / Research Areas of Interest
- Research
Title of Dissertation: "Characterizing the role of APC/CCdh1 ubiquitylation to regulate UHRF1 during cell cycle progression."
Title of Dissertation: "Characterizing the roles of SCF(Cyclin F), and its substrates, in cell cycle progression"
Job Titles:
- Administrative Staff Member
- Executive Assistant to the Chair
Mimi Baltz
Executive Assistant to the Chair
Office: 4017 GMB
my.le@unc.edu
Title of Dissertation: "Development of a cellular analysis platform featuring arrays of patterned microwells fabricated atop permeable supports"
Job Titles:
- Lab Manager
- Research Associate
- Research Associate, Pharmacology & UNC Metabolomics and Proteomics ( MAP ) Core
Natalie is from the small Midwest town of Valparaiso, Indiana. She earned her B.S. from Indiana University Bloomington, where she studied Psychology and Neuroscience. She joined a research lab with Dr. Traci Czyzyk and studied the orphan gene MPZL3. This led her to a job at Mayo Clinic Scottsdale where she was a lab manager in Dr. Czyzyk's lab for three years. She began doing Proteomics as part of the research they were conducting and liked it so much she joined the Proteomics Core at Mayo Clinic with Dr. Paul Langlais. When Dr. Langlais moved his lab to University of Arizona to start a Proteomics Core, Natalie went with as Assistant Director. She worked at the UofA Proteomics Core for three years. After that, she and her family had had enough of the desert and decided to move to NC. She joined the MAP Core (Formerly the UNC Proteomics Core) in 2019 as Lab Manager. Natalie specializes in instrumentation, phosphoproteomics, and sample preparation and optimization.
Job Titles:
- Associate Professor
- Associate Professor, Pharmacology Director, Core Facilities
Job Titles:
- Advisor
- Associate Professor
- Associate Professor, Pharmacology Member, Lineberger Comprehensive Cancer Center / Research Interests
Job Titles:
- Assistant Professor / Sondek Lab
Job Titles:
- Distinguished Professor
- Research
Job Titles:
- Administrative Staff Member
- Business Manager
Title of Dissertation: "Delineating and rationally perturbing signaling mechanisms involved in metastasis"
Title of Dissertation: "Uncovering structural components of the adeno-associated viral capsid that can be modified to enhance clinical gene therapy applications"
Title of Dissertation: "Virion components and subcellular parameters that impact trafficking, nuclear targeting, and infection of adeno-associated virus"
Job Titles:
- Research Associate / Schisler Lab
Title of Dissertation: "Structural basis for ligand-binding and activation of D1-like dopamine receptors"
Job Titles:
- Advisor
- Professor and Vice Chair, Research and Education / Research: Signaling Mechanisms of G Protein - Coupled P2Y Receptors Antibiotic Resistance Mechanisms
Research: Signaling mechanisms of G protein-coupled P2Y receptors; antibiotic resistance mechanisms
Title of Dissertation: "Probing the mechanisms of antibiotic resistance in the gonococcus"
Job Titles:
- Advisor
- Director, UNC - Olympus Imaging Center Fellow of the American Association for the Advancement of Science Member, Lineberger Comprehensive Cancer Center
- Distinguished Professor
- Research
Research Interests
Morphodynamics, adhesion and immune signaling.
Molecules for imaging
Job Titles:
- Assistant Professor
- Associate Professor
- Research Associate
- Research Specialist
- Research Technician
- Applications Analyst, Lab Manager
Job Titles:
- Advisor
- Boshamer Distinguished Professor Emeritus / Research: Molecular Therapeutics
Job Titles:
- Distinguished Professor
- Research
Job Titles:
- Assistant Professor, UNC - CH
Job Titles:
- Assistant Professor / Crews Lab
Job Titles:
- Advisor
- Professor Emeritus / Research: Gene Expression by Antisense Oligonucleotides and
Title of Dissertation: "Modification of Bcl-x and Mcl-1 pre-mRNA splicing using splice-switching oligonucleotide."
Job Titles:
- Professor, Roper Investigator / Director, UNC Gene Therapy Center
Job Titles:
- Sanford Steelman Distinguished Professor & Chair of the Department of Pharmacology Member, Lineberger Comprehensive Cancer Center / Research Interests
- Sanford Steelman Distinguished Professor and Chair of the Department
Job Titles:
- Distinguished Professor
- Research
Research: Ras protein superfamily; signal transduction and oncogenesis
Job Titles:
- Research Associate
- Research Associate, Pharmacology & UNC Metabolomics and Proteomics ( MAP ) Core
Scott was born and raised in Albany, NY. During his B.S he was an Intern at Albany Medical Center (AMC) where he got his first taste of academic bench work. After graduating he became lab manager at AMC for 3 years before applying for graduate school. He went to Dartmouth College and obtained his Ph.D in biochemistry in the lab of Arminja Kettenbach studying phosphoprotein phosphatases and learning about protein mass spectrometry. After graduating in 2020 he became a postdoctoral fellow at Duke Molecular and Physiological Institute (DMPI) under the mentorship of Paul Grimsrud and Deb Muoio. He advanced his knowledge of mass spec-based proteomics and applied it to the study of mitochondria in several metabolic diseases. He started as a Research Associate here at the MAP core in 2023 where he focuses on expanding our data analysis methods using R and python.
Job Titles:
- Research Associate / Calabrese Lab
Job Titles:
- Assistant Professor
- Research Technician
Job Titles:
- Research Instructor / Sondek Lab
Job Titles:
- Advisor
- Kenan Distinguished Professor Emeritus / Research: G Protein - Mediated Signaling
Job Titles:
- Professor and Course Coordinator, Pharmacology Program, Wellbeing Liaison
Job Titles:
- Advisor
- Distinguished Professor and Director, Bowles Center for Alcohol Studies
- Research
Title of Dissertation: "Sex-specific regulation of pain: A novel role for dopamine and corticotropin releasing factor signaling in the midbrain and extended amygdala"
Job Titles:
- Research Technician
- Research Technician, Pharmacology & UNC Metabolomics and Proteomics ( MAP ) Core
Thomas was born and raised in Salisbury, NC. He received his B.S. in Chemistry from the University of North Carolina at Chapel Hill in May 2020, where he performed undergraduate research in the Glish Lab focusing on developing methods for identifying carbohydrates using ion-trap mass spectrometry. Thomas joined the MAP Core as a Research Technician in March 2022 and specializes in proteomics sample preparation for LC-MS analysis, but also assists with method development, instrumentation, and intact mass data analysis.
Job Titles:
- Professor and Co - Director, Computational Medicine Program / Research: Mathematical Modeling of G Protein and MAP Kinase Signaling Pathways
Job Titles:
- Research Technician / Sondek Lab
Job Titles:
- Research Specialist / Nicely Lab
Job Titles:
- Research Associate / Crews Lab
Job Titles:
- Associate Professor
- Director
- Associate Professor, Pharmacology & UNC Metabolomics and Proteomics ( MAP ) Core
- Research Associate Professor, Associate Director of Metabolomics
Whitney received her B.S. in Chemistry from North Carolina State University and her Ph.D. in Analytical Chemistry from the University of Florida. Her doctoral research focused on developing matrix-assisted laser desorption/ionization tandem mass spectrometry and mass spectrometric imaging techniques for analyzing lipids and metabolites in biological tissues. As a postdoctoral fellow and Chemist at the Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Whitney specialized in developing and validating analytical methods for the quantification of toxins in foods and dietary supplements. Subsequently, Whitney held positions as a Senior Research Scholar in the Molecular Education, Technology, and Research Innovation Center and as a Research Assistant Professor in the Department of Molecular and Structural Biochemistry at North Carolina State University. In 2024, she joined the MAP Core team as Associate Director of Metabolomics and Research Associate Professor in the Department of Pharmacology. Whitney is establishing new services for targeted and untargeted metabolomics and lipidomics.
Job Titles:
- Distinguished Professor
- Research
Job Titles:
- Associate Professor / School of Pharmacy
Job Titles:
- Research Technician / Aleman Lab
Job Titles:
- Advisor
- Professor
- Research
Title of Dissertation: "Microglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawal."
Job Titles:
- Associate Professor / Research: Mechanisms That Underlie Various Affective Disorders Including Anxiety Disorders, Depression and Substance Abuse
Research: Mechanisms that underlie various affective disorders including anxiety disorders, depression and substance abuse