TRANSQST

The TransQST project is gathering together existing data and will generate new data under the project goals to support the development of tools that should make it easier to assess the safety profile of drug candidates before undergoing clinical testing phase. This will be achieved by an increased understanding of when results in nonclinical testing can be reliably extrapolated to humans, and by developing models to predict exposure-based biological responses in human tissues, which is an important element of safety assessment for all new drug candidates. Since liver, kidney, cardiovascular and gastrointestinal-immune systems are among more common target organs when safety signals are encountered during clinical testing, TransQST work focuses on these four systems.