GEELEHERLAB

The Geeleher Lab is associated with the Department of Computational Biology, the Graduate School of Biomedical Sciences and the Comprehensive Cancer Center at St. Jude Children's Research Hospital in Memphis Tennessee... The poor outcomes in pediatric solid tumors are explained at least in part by striking intratumoral cellular plasticity, where isogenic cells have been shown to interconvert between different drug-resistant cell states. In the last 5 years, vast strides have been made in our ability to study patient tumor heterogeneity using high-throughput genomics methods like single cell and spatial transcriptomics. In parallel with these developments, we have gained the ability to drug and CRISPR screen very large numbers of preclinical disease models, for example, enormous panels of cancer cell lines. However, our ability to jointly leverage these new classes of data is lacking. For example, while screening in cancer cell lines is highly scalable and has yielded clinically..