T1D, TRIALNET - Key Persons
Dr. Michels laboratory at the Barbara Davis Center for Diabetes is focused on studying the immunology of autoimmune diseases, with a particular focus on type 1 diabetes. Having lived with type 1 diabetes for the more than 20 years, it is Dr. Michels career goal to contribute to the prevention and ultimately a cure for the disease.
Job Titles:
- Professor of Pediatrics at the Barbara Davis Center for Diabetes
Dr. Steck is a Professor of Pediatrics at the Barbara Davis Center for Diabetes at the University of Colorado. Dr. Steck's primary research focus is in the area of epidemiology, immunogenetics, prediction and prevention of type 1 diabetes. Her research interest and expertise include work with large longitudinal prospective studies such as DAISY (Diabetes Autoimmunity Study in the Young), TEDDY (The Environmental Determinants of Diabetes in the Young), ASK (Autoimmunity Screening for of Kids Program) and the Twin Family Study. Dr. Steck is the Center Director for Type 1 Diabetes TrialNet at the University of Colorado and is actively involved in type 1 diabetes prevention and intervention trials through both Industry and NIH TrialNet.
Originally from Ohio, where she did her undergraduate and medical school training, she came to Indianapolis for her pediatric residency at Indiana University. She then completed her pediatric endocrinology fellowship at Indiana University, and during that time also received a certificate in clinical research. Her main research area has been in diabetes. She is interested in both prevention, technology and overall improving care for patients with diabetes. In addition she remains an active clinician, seeing both diabetes and endocrine patients, as well as spear heading quality improvement initiatives for the department.
Belle is the Research Assistant on Dr. Gaglia's immunobiology research team at the Joslin Diabetes Center. She received her Bachelor of Science degree in Human Biology, Health and Science, with minors in Gerontology, Health Policy, and Infectious Disease from Cornell University in 2021. Belle joined the TrialNet team in June 2022, and she is excited to work on clinical trials studying the prevention and intervention of type 1 diabetes in children and adults.
Job Titles:
- Clinical Trials Programme Manager
Job Titles:
- Research Coordinator, CDCES
Job Titles:
- Director, Diabetes Clinical Research Program, TrialNet Chair
Dr. Greenbaum joined the Benaroya Research Institute (BRI) in 2000, where she is a Member and serves as Director of the Diabetes Research Program and the BRI Clinical Research Center. Dr. Greenbaum serves on the Board of Directors for BRI and is a member of the BRI Institutional Review Board, which provides oversight for clinical studies. She currently serves as Chair of Type 1 Diabetes TrialNet
The long-range goal of the Evans-Molina lab is to define the pathways that govern beta cell function in states of health in order to understand how these regulatory circuits are impaired in the pathologic state of Type 2 diabetes mellitus. The major focus of the lab is to characterize changes in expression and activity of the sarco-endoplasmic reticulum Ca2+ ATPase or SERCA pump in the diabetic beta cell and to identify the downstream effects of SERCA dysregulation on ER calcium homeostasis, insulin production and secretion, and beta cell survival.
Job Titles:
- Clinical Research Coordinator
David is one of the Clinical Research Coordinator's on Dr. Gaglia's immunobiology research team at the Joslin Diabetes Center. He graduated from Boston College in 2021 with a Bachelor of Science degree in biology. Throughout his undergraduate experience, he worked under Dr. Emrah Altindis to study the effects of Parabacteroides distasonis on the gut microbiome in hopes to define a potential link between Type 1 Diabetes pathogenesis and the gut microbiota. His interest in immunobiology continues to inspire his work with TrialNet.
Dr. Kurt Griffin earned his PhD (1996) and MD (1998) from the University of Colorado. He completed his general pediatric training at Rainbow Babies and Children's Hospital in Cleveland then subspecialty training in Pediatric Endocrinology at the National Institutes of Health in Bethesda, MD. He has particular experience in clinical management of endocrine tumors and type 1 diabetes. Dr. Griffin takes a collaborative approach with patients and their families and believes that improved understanding of the disease by the patient and family leads to improved care. Particularly with type 1 diabetes, success requires ongoing, in-depth education that must be tailored to each family, and evolves over time as the patient grows older. He has extensive research experience spanning from bench to bedside, with a particular emphasis on the immunology of type 1 diabetes. Dr. Griffin has been an investigator with TrialNet since 2009.
Job Titles:
- Professor of Clinical Diabetes
Dr. Robin Goland, J. Merrill Eastman Professor of Clinical Diabetes, Professor of Medicine and Pediatrics at Columbia University, directs the patient care and clinical research programs at the Berrie Center. She was instrumental in establishing the Naomi Berrie Diabetes Center in July 1998. Under the leadership of Dr. Goland and Berrie Center Co-Director Dr. Rudolph Leibel, the Berrie Center has become recognized nationally and internationally for excellence and innovation in patient care and research in diabetes. Dr. Goland has a B.A. from Harvard University and an M.D. from Columbia University College of Physicians & Surgeons. She was a resident and chief medical resident at NY-Presbyterian Hospital and did her endocrinology research training at Columbia University.
Fadi Al Muhaisen, MD, FAAP is a Pediatric Endocrinologist and the Co-Medical Director of the Endocrine Disorders in Cancer patients clinic. He has a joint appointment at the Kansas University-Wichita School of Medicine as a Clinical Assistant Professor. His expertise is in the use of clinical and research to improve management of clinical trials and health care delivery, and in the care of children and adolescents with Type 1 Diabetes. His role in the Clinical Center is recruiting and assisting in prevention trials. Dr. Al Muhaisen is a member of the American Academy of Pediatrics, board certified, and a member of Pediatric Endocrine Society
Job Titles:
- Clinical Research Coordinator
Hannah is one of the Clinical Research Coordinator's on Dr. Gaglia's immunobiology research team at the Joslin Diabetes Center. She received her Bachelor of Science degree in Computer Science with a minor in Molecular Biology from Bowdoin College in 2022. Hannah joined the TrialNet team in March of 2022, where she has been working on a variety of clinical trials studying type 1 diabetes in children and adults. Hannah was diagnosed with type 1 diabetes in 2016 and has previously worked in various diabetes research labs and as a camp counselor at the Joslin summer camp.
Dr. Ismail attended medical school in Cairo, Egypt. She earned her MBBCh (MD) degree with honors from Cairo University, Faculty of Medicine in 1999. She completed her residency and pediatric endocrine training at Cairo University Children's Hospital. Dr. Ismail later moved to the United States where she completed her US residency training at T.C. Thompson Children's Hospital in Chattanooga, TN and her pediatric endocrine fellowship training at Seattle Children's Hospital. Dr. Ismail became the Clinical Director of the Weight Management Program at Children's Hospital of Pittsburgh in 2014 and the Clinical Director of the Diabetes Program there in 2016. Dr. Ismail joined the faculty at IU School of Medicine in 2018. She is board certified in Pediatrics as well as Pediatric Endocrinology. Dr. Ismail has a primary interest in type 1 diabetes research as well as clinical management of diabetes.
Dr. Gaglia's research has been focused on immunology and type 1 diabetes. His accomplishments include cloning the immune regulatory molecule TIM-3, being a member of the National Institutes of Health Clinical Islet Transplant Program, and leading a clinical trial demonstrating the feasibility of using magnetic resonance imaging to measure inflammation in the pancreas with the development of type 1 diabetes.
Dr. Simmons joined the faculty in 2016 as a physician scientist studying the clinical immunology of autoimmune disease, with a focus on type 1 diabetes. Her current research interests are to screen children in the general population for islet autoantibodies (early T1D), hone techniques to study the immune cells that participate in the pathogenesis of T1D and participate as an investigator in prevention trials with the goal of finding an intervention that can modulate the autoimmune attack in the pancreas. She has received a JDRF Career Development Award, and K12 award to support this work. She is also an investigator of the Autoimmunity Screening for Kids program and of Type 1 Diabetes TrialNet with a specific interest in following patients who are enrolled in immune prevention trials.
After graduating from Harvard University with honors, Dr. DiMeglio obtained her MD from the University of Pennsylvania in Philadelphia, PA and performed her residency in Pediatrics at Children's Memorial Hospital (Northwestern University) in Chicago, IL. She completed her fellowship in Pediatric Endocrinology and received her Master's in Public Health from Indiana University-Purdue University, Indianapolis. Since her fellowship, Dr. DiMeglio has been working in clinical research with a focus on Type 1 diabetes prevention and treatments, including new technologies and therapies for metabolic bone disease. She currently directs Riley Hospital's participation in a number of type 1 diabetes research networks and supervises a research staff of 5 nurses and three technicians. She also collaborates on a variety of other translational and clinical research projects. She is an active clinician, seeing patients with diabetes and endocrine disorders in clinics, and she teaches medical students, residents, housestaff, and fellows.
Job Titles:
- Family Nurse Practitioner
Maria Koen is a Family Nurse Practitioner and Certified Diabetes Educator who has specialized in the care of patients with diabetes since 2001. Her clinical and research interest areas include management of Type 1 diabetes, advanced technologies including pump therapy and CGM systems and modalities aimed at prevention of diabetes. In her role as a clinical research nurse practitioner, she conducts research focused on improvement in glycemic control and/or preservation of beta cell function in individuals with Type 1 diabetes.
Job Titles:
- Co - Principal Investigator for the Clinical Center at Children 's Mercy Hospital
Dr. Clements is Co-Principal Investigator for the Clinical Center at Children's Mercy Hospital in Kansas City. His primary interests in diabetes research have been prevention of diabetes and its complications, and the use of big data predictive analytics to improve diabetes care. He is a Certified Physician Investigator through the Association of Clinical Research Professionals. Dr. Clements has been at Children's Mercy Hospital for 13 years. He attended Butler University, then trained in the Medical Scientist Training Program (MD/PhD program) at Washington University in St Louis. He completed his Pediatric Residency and Endocrine/Diabetes Fellowship at Children's Mercy Kansas City.
Dr. Gottlieb's research focuses on understanding the cause of autoimmunity which leads to type 1 diabetes and other related diseases. He has focused on learning about different components of the immune system which may contribute to disease development. As a logical extension of this basic science work, he has been involved in clinical trials in prediabetes and new and recent onset type 1 diabetes patients for 15 years. He has been the principal investigator in investigator-initiated as well as multicenter trials and participates in trial networks such as Type 1 Diabetes TrialNet.
Ryan McDonough, DO, FAAP is a Pediatric Endocrinologist and the Co-Medical Director of the Children's Diabetes Center. His expertise is in the use of clinical and medical informatics to improve management of clinical trials and health care delivery, and in the care of children and adolescents with Type 1 Diabetes. His role in the Clinical Center is recruiting and assisting in prevention trials. He completed his medical school at Des Moines University in Des Moines, IA, and Pediatrics Residency and Pediatric Endocrinology & Diabetes Fellowship at Children's Mercy.
Job Titles:
- Paediatric Research Nurse
Dr. Triolo joined the faculty in 2019 as a K12 awardee at the Barbara Davis Center. The main focus of her research is to merge clinical investigations with basic science research strategies in the field of type 1 diabetes. As a clinical research investigatory, her work has focused on understanding the development of autoantibodies and progression to type 1 diabetes. Her basic science research is focused on the role of high-risk type 1 diabetes genes in human beta cell function using stem cell derived beta cells. Her goal in her research is to further combine clinical observations to inform basic science investigations.
Job Titles:
- Research Assistant Practitioner
Job Titles:
- Co - Principal Investigator for the Clinical Center at Children 's Mercy Hospital
Dr. Moore is Co-Principal Investigator for the Clinical Center at Children's Mercy Hospital in Kansas City. His primary interests in diabetes research have been prevention of diabetes and its complications at a translational and clinical level. He is a Certified Physician Investigator through the Association of Clinical Research Professionals. Dr. Moore has been at Children's Mercy Hospital for over 20 years and was at University of Kansas Medical Center prior to Children's Mercy. MD, PhD and Pediatric Residency were completed at University of Minnesota.