MARGOLIS LAB

We are located in the Wood Basic Science Building in the Department of Biological Chemistry at the Johns Hopkins University School of Medicine. Our laboratory studies the molecular pathways that control protein turnover and maintain protein homeostasis in developing neurons using biochemical purification, molecular tracing, imaging and behavioral approaches. We aim to understand at a protein level the mechanisms by which the nervous system early in development controls protein synthesis and degradation in order to control when, where and to what extent excitatory synapses will develop. We are particularly interested in understanding these early developmental pathways as we have determined that several of them are aberrantly activated in neurodevelopmental and neurodegenerative disorders. In an effort to extend our hypothesis that these pathways play significant roles in contributing to the developmenat of these disorders we have ongoing efforts using stereotacitic injections and animal..

Primary location: Baltimore United States