IMMUNODB

We are working on developing a dynamic model of immune response to systemic infection leading to sepsis. In collaboration with Dr. Nair group at UCR and the RUHS ICU clinical group we focus on early stages of sepsis caused by Gram negative bacterial species, especially urinary tract E. coli. We hypothesize that early stages of the host immune response and specifically the dynamics of changes in the immune cell populations that define a trajectory leading away versus back to the equilibrium are critical for the outcome in the later stages of sepsis. In this proposal we aim to collect a unique set of longitudinal blood samples from sepsis patients, focusing on a frequent sampling of early phases of sepsis and to develop a novel approach to describe and, eventually, predict dynamics of sepsis progression by a computational modeling... Our group focuses on understanding intra- and inter-cellular networks and especially on how mutations and other genetic changes can remodel and disrupt..

Also known as: Godzik Lab