ROAN LAB

Our lab is interested in studying how cellular and soluble components of the tissue mucosa can influence reproductive health and susceptibility to viral infections... Welcome! The Roan Lab studies the molecular interactions between RNA viruses and T cells, in the context of viral immunity, persistence, and pathogenesis. We study the mechanisms by which intracellular and extracellular factors in the tissue microenvironment that can affect HIV transmission through mucosal sites. We use a variety of multi-omics single-cell analysis approaches, including CyTOF and single-cell sequencing, paired with bioinformatics analyses, to characterize the mechanisms by which HIV persists in people living with HIV despite suppressive antiretroviral therapy (ART), and to discover ways to achieve ART-free HIV control. Multi-omics tools are also being used to characterize T cell immunity in the context of SARS-CoV-2 infection and vaccination, as well as immunopathogenesis in the context of acute COVID-19..

Primary location: San Francisco United States