SFB 1361

Within the SFB 1361, we aim to understand the regulatory mechanisms that control the choice between the individual pathways in the context of chromatin, the cell nucleus and the cell's physiological state in general, their fidelity and their interdependencies in response to different insults... During its first funding period (2019-2022), the SFB 1361 made ground-breaking advances in characterizing the components of DNA repair and DNA damage signalling pathways that act as decision-makers in the regulation of genome maintenance. Structural studies have provided insight into the mechanisms of DNA damage signalling at DNA double-strand breaks, and genomic approaches have revealed the origins of oncogenic chromosome aberrations resulting from such lesions. Overall, the research has highlighted the relevance of endogenous factors as sources of genome instability... Regulation of DNA Repair and Genome Stability. Within the SFB 1361, we elucidate the molecular mechanisms that modulate the..

Primary location: Mainz Germany