CALIFORNIA INSTITUTE OF TECHNOLOGY

Our lab studies the basic mechanisms--including fusion-fission dynamics, degradation, and interactions with other organelles--that control mitochondrial function. We explore the role of mitochondrial dynamics in cellular physiology, development and human disease. In addition, we study other aspects of mitochondrial biology, including organellar quality control and biogenesis... Mitochondria are organelles that act as the power generators of the eukaryotic cell, due to their efficient generation of ATP through oxidative phosphorylation (OXPHOS). In addition, mitochondria are the sites of the tricarboxylic acid (TCA) cycle, fatty acid oxidation, and numerous other metabolic pathways. However, mitochondria have functions far beyond energy metabolism-they play central roles in apoptosis, intracellular calcium handling, reactive oxygen species (ROS) generation and signaling, innate immunity, phospholipid synthesis, and iron-sulfur cluster biogenesis. Given these important functions, it is..

Primary location: Pasadena United States