BERTO LAB

Our laboratory aims to understand the cellular and molecular basis of human brain development and neurodevelopmental disorders. By combining human in-vitro models such as 2D neurons and 3D organoid cultures with advanced genomic approaches, we aim to study genes involved in autism and neurodevelopmental disorders (NDD)... In particular, we are deeply committed to study the role of CHAMP1, a high-risk NDD gene, in human brain development. By using patient-derived iPSC combined with single cell multiomics and electrophysiology, we are characterizing the effect of different mutations in developing human neurons and cortical organoids. Our ultimate goal is to develop new treatments for this rare human neurodevelopmental syndrome... We are actively looking for motivated graduate students and post-doc candidates.

Primary location: Charleston United States