COMPLETE OMICS - Key Persons
Christopher Adewole is working with Complete Omics as a Bioinformatician. He is an undergraduate student attending the University of Maryland, Baltimore County, and double-majoring in Biochemical Engineering and Bioinformatics/Computational Biology. In addition to his part-time work with Complete Omics, Chris serves as a Peer Tutor for student-athletes, an Exam Proctor, and as a Residential Assistant on campus. Chris' work at Complete Omics is centered around engineering automated protein data retrieval tools and methods. The goal of this research is to design a tool that will expedite data-collection towards proteomics research and to develop a template for the research and implementation of scoring heuristics to identify the most viable proteins for clinical trials based on peptide structure and uniqueness. Chris is excited to explore computer science applications towards clinical research and hopes to uncover new possibilities for chemical engineering approaches to bioinformatics and vice versa.
Job Titles:
- Member of the Leadership Team
- CSO and Director for Center of Advanced Proteomics
- Professor
- Professor of Pathology
Dr. Hui Zhang is a Professor of Pathology, Oncology, Chemical and Biomolecular Engineering, and Urology, the Director of Mass Spectrometry Core Facility and Proteomic Research, and the Director for Center for Biomarker Discovery and Translation at Johns Hopkins University.
Dr. Hui Zhang graduated from Peking University with a BS and a MS degree and from University of Pennsylvania with a Ph.D. degree. She then worked at New England Biolabs and Cell Signaling Technology, where developed novel antibodies that are broadly reactive to protein post-translational modifications (PTMs) such as phosphorylation, acetylation, sulfation, etc.. She further invented method for proteomic characterization of protein modifications using the broadly reactive PTM-antibodies and mass spectrometry.
She is the inventor for the PTM-antibody development (Production of motif-specific and context-independent antibodies using peptide libraries as antigens. US Patent 7,259,022) and the immunoaffinity isolation of modified peptides from complex mixture using the PTM-antibodies (Immunoaffinity isolation of modified peptides from complex mixtures. US Patent 7,198,896). After moving to the Institute for Systems Biology in 2001, she pioneered the glycoproteomic technology and applied the glycoproteomic technology to the characterization of cell surface proteins and transmembrane proteins for the discovery of cell surface glycoprotein for therapeutic targeting as well as proteins from body fluids for the discovery of proteins that are either shed or secreted from cancer cells. She is the inventor on glycoproteomic characterization method (Methods for quantitative proteome analysis of glycoproteins. US Patent 7,183,118) and the targeted proteomic technology using affinity capture of native and heavy-isotope labeled peptides and mass spectrometric detection (Affinity capture of peptides by microarray and related methods. US Patent 7,794,947).
She was recruited to Johns Hopkins University in 2006, where she further developed glycoproteomic methods for quantitative site-specific glycosylation characterization and glycan imaging (Mass spectrometry imaging of glycans from tissue sections and improved analyte detection methods. US Patent 11,022,613; Quaternary ammonium containing isobaric tag for quantitative glycan profiling. US Patent 10,254,291; Isobaric aldehyde-reactive tags for and analysis of glycans using same. US Patent 20150241437A1). She applied the methods for proteogenomic characterizations of ovarian cancer, kidney cancer, pancreatic cancer, gastric cancer, endometrial cancer, brain cancer, prostate cancer, etc (Biomarkers for prostate cancer. US Patent 8,603,734).
Her contributions to quantitative proteomics, glycoproteomics, targeted proteomics, and proteogenomics are published in about 300 publications including 3 Nature Biotechnology, Cell, Cancer Cell. Her work has been cited for over 27,000 times.
Job Titles:
- Member of the Leadership Team
- Expert
- VP for Proteomics
Dr. Raghothama Chaerkady is a highly accomplished expert in biochemistry, proteomics and known for his exceptional academic achievements. He earned a Ph.D. degree in Biochemistry in 1999 and later pursued…...
Hamza Umar is major in Mechanical Engineering and he has held various student leadership positions at Howard Community College, participated in a physics-related project, and published a physics paper on Chaos Theory in a double pendulum problem. He then joined the University of Maryland Baltimore County, and at UMBC he has been a teaching assistant for Calculus, a lab assistant for Pre-calculus, and an engineering Teaching Fellow for Computational Methods for Engineering. He is working in Complete Omics on a pioneering project related to 3D printing and material engineering and he wishes to make a direct contribution to the healthcare of human beings.
Jayden is a senior at Johns Hopkins studying Computer Science and is staying at JHU through 2023 to pursue his M.Eng. in Computer Science. Jayden is from Woodside, California, and is also a member and captain of the Varsity Water Polo team at JHU. He also helps lead a student-run VC fund based out of Johns Hopkins, A-Level Capital, where he focuses on the firm's efforts in the intersection of computer science and life sciences.
Having a strong interest in engineering/mathematics and coming from a medical family, Jayden's interests lie in the applications of computer science within medicine and healthcare. Jayden is focusing his current academic endeavors on data science/ML and other computational biology methods, with the ultimate goal of starting his own entrepreneurial endeavor within the medicine or healthcare space. In his free time, Jayden loves to read, cook, hike, and swim.
Job Titles:
- Member of the Leadership Team
- VP for Metabolomics
Liang Zhao received his Ph.D. degree of Analytical Chemistry in 2011 from University of the Pacific. He then continued his research in analytical chemistry by pursuing a post-doctoral training in Johns Hopkins University Center for Alternatives to Animal Testing (CAAT) at the Bloomberg School of Public Health.
In 2012, he took the initiative, as a core member, in establishing the CAAT center's metabolomic core facility and took the leadership for two research projects related to toxicological mechanism studies using a variety of metabolomic technologies. In 2014, he reported a high-throughput metabolic profiling strategy which made characterization of a series of in vitro 3D brain models possible for the prediction of developmental neurotoxicity and neurodegeneration. His work was published on PNAS.
After joining the School of Medicine in Johns Hopkins University as a faculty member in 2017, his research interest has been focusing on tumor- and immuno- metabolomics. As the only faculty member dedicated to metabolomics in the center, he is responsible for project design, training graduate student and lab management. In his research of this period of time, he led his team and developed a stable isotope labeling (carbon/nitrogen tracing) technique to explore the metabolic activities of different cell subsets in tumor micro-environment. With this state-of-the-art approach he has developed, a series of surprising differences in metabolic pathways fueling cancer cells and effector T cells were discovered and a representative work was recently published on SCIENCE in 2019. Now his discoveries are being further exploited as a metabolic checkpoint for a variety of novel cancer therapeutics by numerous research institutions and pharmaceuticals.
He is striving in integrating mass spectrometry, molecular biology and bioinformatics to explore the biomedical importance of metabolites, and to better translate metabolomics findings into clinical applications, such as the development of new biomarker and AI-enhanced diagnostic panels, as well as exploring novel therapeutic approaches for cancers.
Job Titles:
- Chief Intellectual Property Officer
- Member of the Leadership Team
- Scientific Advisor
Ming Zhang obtained her Bachelor's degree and her PhD degree in Department of Molecular Biology and Biochemistry from Nankai University with a research focus on disease-causing gene identification and signaling pathway analysis. She then pursued her Postdoctoral training in the University of Rochester in New York, USA and joined Johns Hopkins University School of Medicine as a Research Associate Faculty and obtained her certificate of genetics and genome analysis. Her research interest is to develop new NGS technologies and to apply them to cancer diagnostics and therapeutics.
Ming is the only Research Faculty focusing on cancer genome under the direction of Dr. Bert Vogelstein. In recent years, she has finished large-scale cancer genome analysis for numerous human cancers, including pancreatic cancer, GI track cancers, brain cancer, and endometrial cancer, etc. By defining the genomic landscapes of these cancers, her work has supported the identification of cancer-associated biomarkers and therapeutic targets including several kinases and metabolic enzymes, which are now prevailing drug targets under investigation of major pharmaceutical companies. A lot of genetic biomarkers have been identified from Ming's work for early cancer diagnostics and many of them have been approved by WHO and are being used in hospitals globally. In the recent 5 years, Ming and Dr. Vogelstein have published over 30 research papers together on high profile scientific journals, such as The New England Journal of Medicine, Nature Genetics, PNAS, Cancer Discovery, Gastroenterology etc., and her recent findings have been cited for over 7000 times.
In addition to her scientific responsibilities, Ming holds the pivotal role of Chief Intellectual Property Officer at Complete Omics. Accredited by the USPTO as a certified intellectual property agent, she expertly directs the safeguarding and patenting of all intellectual properties developed by the company.
Job Titles:
- Molecular Diagnostic Scientist
Morgan Fair is a Biology graduate from Stockton university, earning her Bachelor of Science degree in 2018. Her career initially led her into the realm of patient care in medicine, where she served as a dedicated Patient Care Technician at Anne Arundel Medical Center, specializing on the General Surgical Unit. However, after witnessing the reactive nature of traditional medicine in post-Covid world, Morgan sought a change. She rekindled her skills in microbiology and embarked on a new journey into the realm of proteomics at Complete Omics. Here, she is fervently engaged in unraveling the intricate world of multi-omics approaches for protein diagnostics, driven by her passion for proactive healthcare solutions. Morgan's commitment to exploring and advancing the field and proteomics makes her a valuable contributor to cutting- edge research in the pursuit of innovative diagnostic pursuits.
Parth Parikh is interested in the interactions of the immune system with pathogens, the development of cancer, and potential treatments/cures. This curiosity drove him to pursue medical school after college. He aspires to become an orthopedic surgeon and serves in the US Navy as a medical officer in a few years. His passion for helping others has never been stronger, and he hopes to do so while he is a part of Complete Omics. With his work on developing novel diagnostics methods, he hopes to help improve current technologies in diagnostics.
Job Titles:
- CEO
- Founder
- Member of the Leadership Team
Dr. Wang graduated from Johns Hopkins University with a PhD, supervised by Dr. Bert Vogelstein at the School of Medicine, and an MHS in Biostatistics, supervised by Dr. Rafael Irizarry…...
Raj Purohit, a double major in chemical engineering and biology, has experience in cell culture, protein expression, and diagnostic assays. His parents moved to Maryland from India and then moved to Lexington, Kentucky, where he was born. When he was four, he moved to Cockeysville, Maryland, and has stayed since. With a large passion for STEM, especially in biotechnology, he has studied and participated in a large variety of different projects in biotechnology developments with numerous labs. He works with Complete Omics to develop cutting-edge technologies for mass spectrometry-based biomarker detection.
Stanley Wang, an undergraduate from UMBC, major in Biochemistry and Molecular Biology, Economics, and minoring in entrepreneurship. In 2019, Stanley was selected to participate in The Shattuck Family Internship Program for Entrepreneurship Innovation and Social Change, which funds and places highly-motivated students from diverse backgrounds in internships to better prepare them to launch start-ups or nonprofits. Stanley showed interests, and after interviews, joined Complete Omics. Stanley created an automatic pipeline for mass spectrometry method building with a minimal amount of human intervention. He had been dedicated to his work, which had facilitated an important clinical project including the method build for over 10,000 protein biomarkers.