INFECTIOUS DISEASES - Key Persons
Job Titles:
- Assistant Professor of Medicine
- Department of Medicine
Job Titles:
- Associate Director
- Clinical Assistant Professor of Medicine / Associate Director, ID Clinic
- Department of Medicine
Ms. Durr serves as the Associate Director of the ID clinic, Quality Improvement Coordinator, Ryan White Program Manager and supervises staff members in the ID clinic. She provides urgent and continuity medical services to those living with HIV. Recent work has focused on implementation of preventive medicine services and treatment of chronic illness in the HIV population.
Job Titles:
- Research Scientist
- Research Assistant Professor of Medicine
Waltmann is a research scientist trained in molecular epidemiology and genomics of infectious diseases. Her long-term career goal is to improve the reproductive and sexual health of individuals at risk of sexually-transmitted infections, especially those at risk of gonorrhea and with a focus on vulnerable or understudied populations, such as women, expectant mothers, and HIV-positive persons.
She strives to conduct thoughtfully designed observational studies to better understand risk factors for STIs and to advance knowledge of gonorrhea immunology by deploying cutting-edge, multi-omic approaches (genomics and transcriptomics) directly on patient samples exposed to gonorrhea and STIs. Waltmann ultimately wants her work to contribute to the improvement of health outcomes in those most at risk of STIs and the licensure of a gonorrhea vaccine.
Job Titles:
- Dean, UNC Eshelman School of Pharmacy
Angela Kashuba, B.Sc.Phm., Pharm.D., DABCP, FCP, is the John A and Margaret P McNeill, Sr. Distinguished Professor and Dean of the UNC Eshelman School of Pharmacy. She has been on faculty at the University of North Carolina at Chapel Hill since 1997 and served as the Chair of the Division of Pharmacotherapy and Experimental Therapeutics from 2015 to 2019. Dr. Kashuba serves as Director of the UNC Center for AIDS Research Clinical Pharmacology and Analytical Chemistry Core and leads a research laboratory focused on optimizing antiretroviral pharmacology in the treatment, prevention, and eradication of HIV infection. Her laboratory has authored over 250 manuscripts and received over $25 million in research funding. She is the recipient of the 2020 ASCPT Rawls-Palmer Progress in Medicine Award, 2017 ACCP (Pharmacology) Honorary Fellowship Award, and 2017 ACCP (Pharmacy) Therapeutic Frontiers Lecture Award.
Job Titles:
- Associate Professor of Medicine
Job Titles:
- Assistant Professor of Medicine
Job Titles:
- Associate Professor of Medicine
Job Titles:
- Assistant Professor of Medicine
The Turner Laboratory is interested in evaluating the epigenetic pathways involved in HIV latency and developing and testing new latency reversal agents for HIV cure strategies. Through collaborations within the HIV Cure Center as well as with groups in the Department of Biochemistry and Biophysics and the Center for Integrative Chemical Biology and Drug Discovery at UNC, we are using small molecule inhibitors, shRNA knockdown, and CRISPR-targeting to evaluate chromatin family proteins in HIV latency. We are also interested in a new class of molecules, bivalent chemical degraders, also known as PROTACs or proteolysis chimeras. These bivalent molecules link a known small molecule inhibitor to a ligand for an E3 ubiquitin ligase and can induce target-specific degradation and represent a new class of molecules for latency reversal cure strategies. New work in the lab surrounds the characterization of integration sites of intact proviruses in donor cells and the local chromatin environment surrounding these viruses. We have recently developed an new assay to map these viruses based on long-read nanopore sequencing. It is possible that detailed characterization of these sites could illuminate novel interactions with major transcriptional features, histone post-translational modifications (PTMs), and chromatin structure previously obscured by abundant defective proviruses and further our understanding how chromatin restrictions govern latency and reactivation.
Job Titles:
- Principal Investigator or Co - Investigator
- Professor of Medicine
Dr. Seña has served as a principal investigator or co-investigator on NIH, CDC and industry supported multi-center trials involving epidemiology, novel diagnostics and therapeutic regimens for sexually transmitted infections (STIs). She was a member of the Scientific Review Committee for the NIH STI-Clinical Trials Group from 2007-2021. Her primary research interest is in syphilis, including vaccine development. She is the Co-Project Director for an NIH STI Cooperative Research Center grant for syphilis vaccine development titled "Global sequence and surface antigenic diversity of Treponema pallidum outer membrane proteins," which involves UNC Project Malawi and UNC Project China. Dr. Seña also has research interests in other bacterial STIs and STI/HIV/hepatitis C public health interventions, having previously served as the Medical and Laboratory Director at the Durham County Department of Public Health from 2001- 2020. Dr. Seña currently serves as a consultant for the NC HIV/STD Prevention and Care Branch and the CDC STD Treatment Guidelines, and is the Treasurer of the American STD Association. She has mentored numerous clinical and graduate level trainees in STI research and public health careers at the academic, state and national level, and has been one of the key faculty members on STI/HIV training grants. Dr. Seña provides care on both the general infectious disease and compromised host services, and sees outpatients in the transplant ID clinic.
Job Titles:
- Assistant Professor of Medicine
Job Titles:
- Associate Professor of Medicine / Co - Director of HIV Services, North Carolina Department of Corrections
- HIV Health Service Researcher
Dr. White is an HIV health service researcher and a practicing infectious disease physician. Dr. White uses her "real world" clinical experience to inform her research. Her research focuses on the dynamic interface between public health and medicine. She was one of the leading physician's who described the association between the release of HIV-infected prisoners and the subsequent deleterious effect (increase) on their viral loads. This connection continues to have significant HIV-transmission and health outcome implications for at-risk populations in the community as well as released prisoners. Furthermore, along with others, she conducted the first randomized controlled trial of directly observed antiretroviral therapy vs. self-administered antiretroviral therapy in a state prison system. She also has participated in the implementation of the first ever HIV-opt out screening in the North Carolina state prison system. She is now expanding her research focus on the HIV at risk community and her research interests span from HIV screening/testing to access and adherence to highly active antiretroviral therapy in underserved populations. Her clinical interests include treatment of HIV infection and syphilis. She invites anyone interested in joining her research team to contact her.
Job Titles:
- Associate Professor of Medicine
Job Titles:
- Charles Addison and Elizabeth Ann Sanders Distinguished Professor of Medicine / Associate Chief Medical Officer, UNC Medical Center
Job Titles:
- Department of Medicine
- FIDSA / Associate Professor of Medicine / Director, North Carolina HIV Training & Education Center
Job Titles:
- Assistant Professor of Medicine / Medical Director, Wake County Human Services HIV and STI Clinics
- Assistant Professor of Medicine / Medical Director, Wake County Human Services HIV and STI Clinics / Program Director, Infectious Diseases Training Program
- Department of Medicine
Job Titles:
- Assistant Professor of Medicine / Medical Director, UNC Infectious Diseases Clinic
- Assistant Professor of Medicine / Medical Director, UNC Infectious Diseases Clinic / Co - Director, UNC Center for AIDS Research Clinical Core
- Department of Medicine
Job Titles:
- Associate Professor of Medicine / Medical Director, UNC HIV Cure Center
- Department of Medicine
Dr. Cindy Gay is a practicing infectious diseases clinician and the Medical Director for the HIV Cure Center at UNC. Her research background includes clinical trials and translational including Phase I/II clinical trials involving novel HIV vaccines and immunotherapeutic strategies to advance HIV cure strategies. Dr. Gay has also worked on HIV-related studies conducted in national networks including the AIDS Clinical Trials Group (ACTG), the HIV Prevention Trials Network, and the HIV Vaccine Trials Network. Dr. Gay is the site Principle investigator for the Moderna COVID-19 vaccine trial as well as a co-chair and site Principle investigator for a Phase 3 trial of the Novavax covid-19 vaccine.
Job Titles:
- Charles Addison and Elizabeth Ann Sanders Distinguished Professor of Medicine / Associate Chief Medical Officer, UNC Medical Center
Job Titles:
- Associate Professor of Medicine
Job Titles:
- Department of Medicine
- Sarah Graham Kenan Distinguished Professor of Medicine / Professor of Microbiology & Immunology, and Epidemiology
- Sarah Graham Kenan Distinguished Professor of Medicine / Professor of Microbiology & Immunology, and Epidemiology / Director, UNC HIV Cure Center
Job Titles:
- Department of Medicine
- Founding Director of the Immunocompromised Host
- Professor of Medicine / Director, Immunocompromised Host Infectious Diseases Section
Dr. van Duin is the founding Director of the Immunocompromised Host ID service. His main research interests are multi-drug resistant Gram-negative bacteria, and infections in immunocompromised patients. He is the PI for the MDRO Network of the Antibacterial Resistance Leadership Group. Within the MDRO Network, the consortium on resistance against carbapenems in Klebsiella and other Enterobacterales (CRACKLE) has been completed. In addition, studies on ESBL-producing Enterobacterales, carbapenem-resistant Pseudomonas aeruginosa, and carbapenem-resistant Acinetobacter baumannii are ongoing. He is also funded to explore the community origins of highly resistant bacteria.
Job Titles:
- Department of Medicine
- Professor of Medicine / Co - PI, UNC Infectious Diseases Clinical Research Trials Unit
- Professor of Medicine / Co - PI, UNC Infectious Diseases Clinical Research Trials Unit / Co - Director, UNC Viral Hemorrhagic Fever Research Group
Dr. Wohl is a Professor of Medicine in the Division of Infectious Diseases at the University of North Carolina (UNC). He is co-Principal Investigator of the Global UNC Infectious Diseases Clinical Trials Unit and Site Leader of its Chapel Hill research site. Dr. Wohl is a clinical scientist with a focus on emergent infectious diseases. He has spent over 20 years leading research into the prevention and treatment of HIV and served two terms as a member of the US Department of Health and Human Services (DHHS) Antiretroviral Guidelines Panel. Since 2014, he has been working continuously in Liberia, West Africa, conducting research with Ebola survivors to learn about chronic complications and sexual transmission of this infection and establishing the UNC Project Liberia research platform at two locations in the country. He and his team have extended this work to examine Lassa fever, a viral hemorrhagic fever endemic in West Africa. In 2020, he helped lead the UNC clinical and research response to COVID-19. He is medical director of a large drive through testing site as well as two COVID-19 vaccination clinics. He serves as Vice Chair of ACTIV-2, an international AIDS Clinical Trials Group (ACTG)/Operation Warp Speed trial of SARS-CoV-2 therapeutics. He has an active clinical practice at UNC.
Job Titles:
- Associate Professor of Medicine
Job Titles:
- Assistant Professor of Medicine
Job Titles:
- Associate Professor of Medicine
Job Titles:
- Assistant Professor of Medicine
Job Titles:
- Associate Professor of Medicine
Job Titles:
- Assistant Professor of Medicine
Job Titles:
- Member of the Division Leadership Team
- Chief, Division
- Professor of Medicine
Job Titles:
- Assistant Professor of Medicine
Job Titles:
- Assistant Professor of Medicine
Job Titles:
- Member of the Division Leadership Team
Job Titles:
- DTM & H / Associate Professor of Medicine
Job Titles:
- Associate Professor of Medicine
Job Titles:
- Associate Professor of Medicine
Job Titles:
- Associate Professor of Medicine
Job Titles:
- Member of the Division Leadership Team
- Associate Chief of Administration
Job Titles:
- Yeargan - Bate Professor of Medicine, Microbiology and Epidemiology / Associate Vice Chancellor for Medical Affairs
Job Titles:
- Assistant Professor of Medicine
Job Titles:
- Associate Professor of Medicine
Job Titles:
- Associate Professor of Medicine / Medical Director, Carolina Antimicrobial Stewardship Program
Job Titles:
- Associate Professor of Medicine
Job Titles:
- Professor of Medicine / Associate Director, Center for AIDS Research
Job Titles:
- Assistant Professor of Medicine / Assistant Professor of Epidemiology
Job Titles:
- Assistant Professor of Medicine / Trainee, Physician Scientist Training Program
Job Titles:
- Department of Medicine
- Sarah Graham Kenan Distinguished Professor of Medicine / Professor of Microbiology & Immunology, and Epidemiology
- Sarah Graham Kenan Distinguished Professor of Medicine / Professor of Microbiology & Immunology, and Epidemiology / Director, UNC HIV Cure Center
Job Titles:
- Associate Professor of Medicine / Associate Professor of Epidemiology, Gillings School of Global Public Health
Job Titles:
- Research Assistant Professor of Medicine
Job Titles:
- Assistant Professor of Medicine
Job Titles:
- Assistant Professor of Medicine
Job Titles:
- Assistant Professor of Medicine
Job Titles:
- Research Associate Professor of Medicine
Job Titles:
- Professor of Medicine / Director, Statewide Program for Infection Control and Epidemiology
Job Titles:
- Assistant Professor of Medicine