PBPREDICTOR

PBPredictor is a web service for predicting the blood-placental barrier permeability of small molecules using relatively light weight computations. PBPredictor predicts the values of two blood-placental barrier permeability indices, logFM and CI... logFM is an in vivo index obtained from the blood concentration ratio of cord blood to maternal blood (F/M ratio). PBPredictor provides predictions from the prediction model by gradient boosting decision tree (LightGBM), which was trained from logFM data collected by Takaku et al. (Takaku T, et al. Biol Pharm Bull, 38(6), 2015)... The CI (clearance index) is an ex vivo index obtained by comparing the rate at which the target compound moves from the maternal side to the fetal side (clearance) in a placental perfusion experiment using the human placenta, the clearance of the control compound antipyrine. PBPredictor provides predictions from the prediction model by gradient boosting decision tree (LightGBM) trained from CI data collected by..