AIBINLAB.ORG

He laboratory is striving for developing and applying new technologies in single-cell omics and in toto live imaging for understanding of gene regulation and tissue-scale cell lineages. Next-generation sequencing (NGS) based multi-modal omics provides rich molecular characterizations with single-cell sensitivity but no cells can be assayed more than once in a destructive manner, while fluorescence microscopy imaging brings about comprehensive spatial and temporal information from morphological description of a tissue/organ building scheme to quantitative molecular and cellular profiling. Currently, the team exploits single-cell omics, such as CoBATCH, sc-itChIP-seq, CoTECH, uCoTarget and scEpichem, to reveal key links between multi-dimensional epigenome with varying chromatin modifications and transcription factors binding and gene transcription shaping cell fates in development and human diseases. Efforts are also made towards designing and applying large field of view and high-..

Primary location: Beijing China