DRUGLOGICS

Originally spearheaded by S. Kauffmann[2] and R. Thomas[3], logical (Boolean) multiscale models have been shown to accurately describe molecular mechanisms underlying cellular decision making[4]. Boolean models can be hand-built from logical statements that are derived from pathway databases, general knowledge bases and the scientific literature. The correctness of models can be checked by observing that logical rules during a simulation/model updating scheme govern model state transitions that evolve to a stable state (or cycle), representing a clearly definable biological or cellular state. Many Boolean modelling software tools are available for this, and some have been used by us, in particular the software suite GINsim[5] which we have used to build an extensive logical multiscale model for the cancer cell line AGS10. Starting with a regulatory network valid for a variety of cells and conditions, the model was configured with baseline phenotypic biomarkers from actively growing AGS..

Also known as: Druglogics Initiative

Primary location: Trondheim Norway