PATIAL LAB

We are testing the hypothesis that certain hepatotoxicants dysregulate TTP family RBP expression, that results in their target mRNA stabilization and associated pathology... Lung Injury and Inflammation: Second, we are testing how TTP, the master regulator of inflammation, regulates the pathogenesis, including initiation, progression, and resolution of ozone- and allergen-induced lung inflammation. We have generated various knockout mice of cell-specific TTP deficiency to answer some of these questions. Besides, bone-marrow chimeras are generated to test the cell-lineage specificity of TTP action... The focus of our research is to understand how post-transcriptional mechanisms of gene expression regulate the pathogenesis of Environmentally-induced Hepatic and Pulmonary inflammation. We are specifically investigating RNA-Binding-Proteins of the Zinc Finger Protein 36 (ZFP36) family. Zinc Finger Protein 36 (ZFP36), also commonly known as Tristetraprolin (TTP) post-transcriptionally..