LIN LAB

Long-read sequencing technologies, using third-generation DNA sequencers from Pacific Biosciences and Oxford Nanopore Technologies, are revolutionizing genomic research. These technologies have exciting transcriptomic applications, allowing direct resolution of transcript isoform structures and interrogation of repetitive RNA sequences. Using state-of-the-art nanopore long-read sequencing devices (MinION and GridION), we are developing new experimental methods to discover and quantify diverse RNA species in bulk tissues and single cells. By comparing the repertoire of full-length RNA transcripts between normal and diseased states (e.g. tumors), we hope to discover molecular markers or therapeutic targets of disease... N6-methyladenosine (m 6 A) is an abundant and dynamically regulated class of RNA base modification in mRNAs and non-coding RNAs. It affects multiple aspects of RNA metabolism and controls developmental transitions by regulating mRNA decay and translation. We are..

Also known as: Lin

Primary location: Philadelphia United States