LSA - Key Persons
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- Associate Professor, NYU School of Medicine Skirball Institute of Biomolecular Medicine, New York NY, USA
Chromosomes are the structural units of our genome. Understanding their basic biology and how their mismanagement leads to disease is the focus of the Sfeir lab. Part of our research aims to investigate the structure and function of the protective elements at the end of chromosome - the telomeres. In addition, the lab investigates the link between dysfunctional telomeres and cancer. In more recent years, we have been building upon our knowledge of nuclear DNA replication and repair to investigate mitochondrial DNA replication and repair and understand the pathways that instigate mitochondrial DNA instability.
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- Professor, University of Cologne, Cologne, Germany
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- Associate Professor
- Associate Professor, Baker Heart and Diabetes Institute, Melbourne, Australia
Associate Professor Andrew Murphy heads of the Haematopoiesis and Leukocyte Biology laboratory and the Division of Immunometabolism at the Baker Heart and Diabetes Institute. He obtained his PhD in 2009 and his postdoctoral studies were completed in Prof. Alan Tall's group at Columbia University. In 2013 he set up his laboratory in Melbourne, where his group largely focuses on how inflammatory diseases associated with cardiovascular disease, including diabetes, obesity and rheumatoid arthritis cause the overproduction of innate immune cells and how this contributes to atherosclerosis. Furthermore, his laboratory studies fundamental biological process regulating haematopoiesis.
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- Professor, Yale University Cardiovascular Research Center, New Haven CT, USA INSERM U970, Paris Cardiovascular Research Center, Paris, France
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- Director, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
Asifa studies the epigenetic regulation by histone acetylation and long non-coding RNAs. In particular, her lab focusses on X-chromosome specific gene regulation at single cell resolution all the way to chromosomal and organismal level, using Drosophila dosage compensation as a model system. More recently, they have expanded their analyses into mouse models.
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- Professor, Université De Genève, Geneva, Switzerland
The Roux lab uses tools and concepts from physics and chemistry to understand how lipid membranes are remodelled by proteins involved in membrane traffic and other membrane-dependent cell functions. The group has shown how forces, energies and elastic parameters (bending rigidity, tension) are essential to our understanding of clathrin mediated endocytosis. More recently, the groups has shown that ESCRT-III complex forms spiral springs which could trigger membrane budding by buckling. The group uses physics tools such has optical tweezers to obtain quantitative experimental results that can be compared directly with theories made by theoretician colleagues, among which Martin Lenz, Orsay has been the main one.
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- Associate Professor, Computer Science Department and Center for Statistics and Machine Learning, Princeton University
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- Associate Professor of Immunobiology and Pharmacology HHMI Faculty Scholar Department of Immunobiology, Yale School of Medicine, New Haven CT, USA
Dr. Rothlin's laboratory is interested in understanding the regulation of the immune response and resolution of inflammation. Her studies have revealed innate immune checkpoints that regulate whether the adaptive immune response would be initiated (threshold), dynamically adjust its magnitude (how much and how long the response should last) and determine its quality (anti-viral versus anti-helminth). These checkpoints also trigger the resolution of inflammation and induction of tissue repair. Rothlin's laboratory also aims to understand the consequences of chronic checkpoint engagement in non-resolving infections and cancer.
Assistant Investigator, Cell Biology and Disease Mechanisms Program, Telethon Institute of Genetics and Medicine; Assistant Professor of Medical Genetics, Department of Translational Medicine, University of Naples "Federico II", Naples, Italy
Carsten Janke is studying the role of tubulin posttranslational modifications in the regulation of microtubule functions. Having discovered several families of tubulin-modifying enzymes, his team is currently investigating how these enzymes alter the functions of microtubules, and how this controls the behavior of the microtubule cytoskeleton in cells and organisms.
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- Professor, Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
Cigall established her independent laboratory in 2014, at age 28, one of the youngest scientists ever appointed to the Harvard Medical School faculty, immediately following completion of her Ph.D. studies in Cancer Biology at Stanford University working with developmental biologist Gerald Crabtree. She has quickly become a leading expert in chromatin and gene regulation and is internationally recognized for her groundbreaking studies in these areas. Specifically, her laboratory studies the structure and function of chromatin remodeling complexes such as the mammalian SWI/SNF (or BAF) complex, with emphasis on defining the mechanisms underlying cancer-specific perturbations. The recent surge in exome- and genome-wide sequencing efforts has unmasked the major, previously unappreciated contribution of these regulators to malignancy: the genes encoding subunits of mammalian SWI/SNF complexes are mutated in over 25% of human cancers.
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- Professor, Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, Freiburg, Germany
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- Associate Professor, Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester MA, USA
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- Professor, Department of Immunology, University of Toronto, Toronto, Canada
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- Professor and Deputy Director, Signature Research Program in Cardiovascular & Metabolic Diseases, Duke - NUS Medical School, Singapore
Dimple is a Wellcome trust/IA fellow and Assistant Professor at National Centre for Biological Sciences India, where she heads the Chromatin Biology group in the Department of Genetics and Development. Her research uses an interdisciplinary approach to understand the dynamic interplay between chromatin organization, regulatory elements and non-coding RNAs in gene regulation. She earned her PhD from NCCS, India and completed her post-doctoral training in Geoff Rosenfeld's laboratory at UC San Diego where her work identified the important roles of enhancers and their non-coding RNAs (eRNAs) in ligand-dependent gene regulation.
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- Professor, Laboratory of Biochemistry, Wageningen University, Wageningen, Netherlands
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- Head, Department of Genome Biology, European Molecular Biology Laboratory ( EMBL ), Heidelberg, Germany
Eileen's research spans the areas of transcription/chromatin regulation and developmental biology using the integration of genetics, genomics, imaging and computational biology. In particular, her laboratory dissects general principles by which developmental enhancers function and how robustness is imparted within developmental programs. How a single genome can generate such a diversity of cells, and how transcriptional networks control and buffer the process of differentiation, are the two overarching questions of her group's work.
In the interface between bioimaging, proteomics and artificial intelligence, the research in the Lundberg lab aims to define the spatiotemporal organization of the human proteome at a subcellular level, with the goal to understand how variations and deviations in protein expression patterns can contribute to cellular function and disease. Emma Lundberg is the Director of the Cell Atlas of the Human Protein Atlas, and has participated in many cell mapping efforts such as the Human Proteome Project and The Human Cell Atlas.
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- Professor, Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester MA, USA
The Baehrecke laboratory studies how autophagy (self-eating) is regulated and functions in complex multi-cellular organisms. Autophagy is a conserved catabolic process that is used to clear materials from cells, helps to maintain cell health and has been implicated in multiple human diseases. We screen for novel mechanisms that control autophagy using genetic and genomic approaches, and determine how autophagy functions to promote cell health and cell death in different cells and tissues within developing animal cells.
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- Department of Biochemistry
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- Professor, University of California, Berkeley CA, USA
The Karpen lab has a long-standing interest in chromatin structure and function, with a special emphasis on heterochromatic DNA regions. The current projects in the lab range from centromere formation and function, to the role of lncRNAs, ageing, and DNA repair in heterochromatin formation and maintenance.
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- Professor, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
Dr. Mo-Fang Liu obtained her Ph.D degree from Shanghai Institute of Biochemistry, Chinese Academy of Sciences in 2000. From 2000 to 2006, she was a postdoctoral fellow in National Cancer Institute, NIH, and then a research assistant at Howard Hughes Medical Institute, Johns Hopkins University School of Medicine. She joined the Shanghai Institute of Biochemistry and Cell Biology in 2006. The major research interests in Liu's group are the roles and mechanisms of noncoding RNAs and their binding proteins, especially of those involved in spermatogenesis and human male infertility. Additionally, they have also engaged in understanding the pathological function and mechanisms of noncoding RNAs in human cancers, especially in inflammation-associated tumorigenesis and tumor cell metabolism.
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- Immunologist
- Professor, German Cancer Research Center, Heidelberg, Germany
Hedda Wardemann is a B cell immunologist with a primary interest in antibody repertoires and the functional evolution of human B cell antibody responses. She uses single-cell immunoglobulin gene repertoire analyses to measure the diversity and to track the clonal evolution of B cells in health and disease. In combination with antibody cloning she aims to assess the quality of human B cell responses and to develop tools to direct antibody responses by targeted interventions, e.g. through vaccination, with a special focus on human Plasmodium falciparum malaria.
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- Principal Investigator, MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
The Ganley Lab is interested in autophagy, a membrane-driven lysosomal degradation pathway, and how this might be targeted to treat disease. The lab is particularly focussed on how signalling leads to mitophagy, the autophagy of mitochondria, and uses a combination of in vitro and in vivo approaches to determine when and where this process is important and how it is regulated.
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- Professor, Ruđer Bošković Institute, Zagreb, Croatia
Professor of Pediatrics; Chief Scientific Officer, Center for Stem Cell and Organoid Medicine (CuSTOM); Perinatal Institute Endowed Professor, Division of Developmental Biology; Director for research, Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati OH, USA
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- Professor, Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
The Veening lab is interested in understanding fundamental processes in the pneumococcus, the main cause of community acquired pneumonia and meningitis in children and the elderly. Using a multidisciplinary approach, including quantitative single cell techniques, systems and synthetic biology, we address how pneumococci grow and divide and segregate their DNA prior to cell division. We are also interested in the role of phenotypic variation for pneumococcal virulence and antibiotic resistance development.
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- Professor, Department of Biochemistry, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City UT, USA
The Rutter laboratory employs a wide array of technologies to enable discovery related to metabolic control as well as fundamental aspects of mitochondrial biology. The Rutter laboratory has characterized the PAS kinase protein as an important factor in states of metabolic dysregulation-including obesity and diabetes. More recently, the Rutter laboratory and collaborators have identified the functions of a number of previously uncharacterized mitochondrial proteins, including the discovery of the long-sought mitochondrial pyruvate carrier. This knowledge has now enabled for the first time the demonstration that this critical metabolic step is impaired in a variety of human diseases, including cancer and cardiovascular disease.
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- Associate Professor, Icahn School of Medicine at Mount Sinai, New York NY, USA
The Chipuk laboratory's long-term goals are to provide: 1) Mechanistic insights of how mitochondrial composition and shape impact on cellular metabolism and commitment to apoptosis, 2) explore how cancer-promoting pathways converge on the mitochondrial function to regulate malignancy and chemotherapeutic success, and 3) to reveal novel contributions of the mitochondrial network in tissue homeostasis.
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- Joint Division Head, Professor, the Walter and Eliza Hall Institute Adjunct Associate Professor, La Trobe University, Melbourne, Australia
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- Associate Investigator at the Stowers Institute for Medical Research, Kansas City MO, USA
Julia Zeitlinger's long-term research goal is to understand and predict gene regulation based on DNA sequence information and genome-wide experimental data. Trained in developmental genetics and transcription, she obtained her Ph.D at EMBL in Germany. She then did postdoctoral work with Rick Young at Whitehead/MIT, where she began using genomics approaches to understand transcription during development. For her innovative approaches, she was named Pew scholar and received the NIH New Innovator Award in 2008. She is currently an Associate Investigator at the Stowers Institute for Medical Research and Assistant Professor at the University of Kansas Medical Centre.
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- Assistant Professor, University of Pennsylvania, Philadelphia PA, USA
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- Director, Gladstone Institute for Data Science
Director, Gladstone Institute for Data Science & Biotechnology; Professor, University of California San Francisco; Investigator, Chan-Zuckerberg Biohub, San Francisco CA, USA
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- Associate Professor, the University of Chicago, Chicago IL, USA
The Macleod Lab researches the role of mitophagy and mitochondrial dysfunction in cancer with a particular emphasis on the functions of the mitophagy adaptor proteins BNIP3 and BNIP3L/NIX in stress responses, such as to hypoxia and nutrient deprivation. Using mouse models and human patient samples, we seek to determine how deregulated expression of BNIP3 and/or BNIP3L in cancers affects rates of mitophagy and contributes to cancer progression to invasive carcinoma and metastasis. In addition, the lab examines how mitophagy is coordinated with mitochondrial biogenesis and how this is deregulated in cancer.
Research in the Miller lab aims to understand genome maintenance and the DNA damage response in the context of chromatin, cancer and anticancer therapies. His lab employs genetics, genomics, cell biology and molecular biology to gain insights into these areas of research in mammalian cells. His lab applies these multifaceted and diverse approaches to these areas of research in hopes of defining the relationship between chromatin and DNA damage responses in DNA repair and disease, as well as gaining insights into the mechanisms of cancer therapeutic drugs that act at the chromatin and DNA level.
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- Professor, CRUK Beatson Institute, Glasgow University College of Medical, Veterinary and Life Sciences, Glasgow, UK
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- Professor, Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora CO, USA
Dr. Sussel's research program focuses on the transcriptional regulation of pancreas development and adult pancreatic islet cell function during physiological and pathophysiological conditions. Most recently, she has pioneered the new field of long non-coding RNAs and their regulation of islet development and function.
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- Senior Scientist, Genentech, South San Francisco CA, USA
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- Programme Leader, MRC Lab of Molecular Biology, Cambridge, UK
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- Professor, Department of Biomedical Sciences, University of Padova, Padova, Italy
Marco Sandri is Full Professor of Pathology at Department of Biomedical Science, University of Padova. He is particularly interested in understanding the signalling pathways that control protein synthesis and degradation and the impact on muscle mass and force generation. He analyses in the involvement of ubiquitin-proteasome and autophagy-lysosome systems in protein breakdown during catabolic conditions. He is also interested in mitochondria and their impact on tissue metabolism and longevity.
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- Professor, Biozentrum, University of Basel, Basel, Switzerland
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- Executive Director, Instituto De Medicina Molecular João Lobo Antunes, Lisbon, Portugal
Parasitology, physiology, molecular medicine, malaria, host-microbe interactions
Our ongoing work indicates that the web of host-Plasmodium interactions is densely woven, with liver stage-mediated innate mechanisms, host nutritional status, and an antagonistic relationship between the two parasite stages themselves all working to modulate the balance between parasite replication and human health. Altering this balance will be required if we aim to efficiently control this deadly parasite.
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- Member of the Whitehead Institute for Biomedical Research Associate Professor of Biology, Massachusetts Institute of Technology, Cambridge MA, USA
The Gehring lab studies plant epigenetics - that is, the heritable information that influences cellular function but is not encoded in the DNA sequence itself. The lab uses genetic, genomic and molecular biology approaches to study the fidelity of epigenetic inheritance and the dynamics of epigenomic reprogramming during reproduction, primarily in the model plant Arabidopsis thaliana. Recently, the lab has focused on the mechanisms and evolution of genomic imprinting, the function and regulation of small RNAs in seeds, and mechanisms that maintain DNA methylation homeostasis across generations.
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- Associate Professor, Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
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- Assistant Professor, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
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- Professor, Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago IL, USA
The Glotzer lab focuses on the mechanisms of cell organization. How do cells position the cleavage furrow? By what mechanisms are cortical domains that mediate cell polarization assembled and maintained? How do cells regulate cortical contractility during morphogenesis? We use a variety of model systems and combine forward and reverse genetics, biochemistry, optogenetics, and live cell imaging. Through these approaches we have discovered and extensively characterized the centralspindlin complex, which regulates every step of cytokinesis. Through optogenetics, we demonstrated that RhoA activation is sufficient to induce cleavage furrows irrespective of spindle position or cell cycle stage.
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- Principal Investigator, Institute of Biochemistry and Cell Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
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- Professor Chair of Biomedical Sciences University of California, Riverside CA, USA
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- Assistant Professor of Neuroscience, MIT, Broad Institute, Picower Institute, Cambridge MA, USA
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- Group Leader, European Molecular Biology Laboratory ( EMBL ), Genome Biology Unit, Heidelberg, Germany
The Typas group develops and utilises high-throughput methods to study the cellular networks of different bacterial species, and how these bacteria interact with the environment and with each other.
Nicolas Fazilleau is a team leader and INSERM Research Director at the Center for Pathophysiology of Toulouse-Purpan, France. He studied at the Pasteur Institute and obtained his PhD in Immunology from the University Paris Diderot. He completed his postdoctoral training at the Scripps Research Institute, La Jolla USA. His research interest is to better understand how humoral responses are regulated by T lymphocytes. Nicolas' lab aims to identify predictive biomarkers and therapeutic targets to improve humoral responses in physiological conditions or revert humoral dysfunction associated with pathologies.
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- Group Leader, European Bioinformatics Institute, European Molecular Biology Laboratory ( EMBL - EBI ), Hinxton, UK
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- Associate Professor, Department of Molecular Medicine, the Scripps Research Institute, La Jolla CA, USA
The Wiseman lab research program focuses on understanding how organellar stress-responsive signaling pathways, such as the Unfolded Protein Response (UPR), integrate to regulate cellular protein homeostasis in response to genetic, environmental or aging-related insults. Through these efforts, we are defining how alterations in stress-responsive signaling contribute to the onset and pathogenesis of human disease. Furthermore, we are identifying specific aspects of stress-responsive signaling pathways that can be therapeutically accessed to correct pathologic imbalances in protein homeostasis associated with etiologically diverse types of disease.
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- Professor, School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
Rafael Carazo Salas' research aims to elucidate how the gene and protein networks that control basic or disease-related processes like cell growth, division and differentiation operate in space and in time within cells, and how those networks allow cells to function as integrated systems and acquire specific fates. To that end, his group develops and uses interdisciplinary quantitative cell biology methods - including 3D high-throughput/high-content microscopy pipelines and Big Data approaches - and human pluripotent stem cells as an experimental system. The group's long-term goal is to understand how to specifically, efficiently and safely program stem cell-derived human tissues for therapeutic applications.
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- Professor and Chairman, Department of Cancer Biology
Professor and Chairman, Department of Cancer Biology; RE Bob Smith Chair for Cancer Research; CPRIT Established Investigator; Director, Metastasis Research Center, MD Anderson Cancer Centre, University of Texas, Houston TX, USA
Raghu Kalluri received his Ph.D. from the University of Kansas Medical Center and his M.D. from Brown University Medical School. Dr. Kalluri was a postdoctoral fellow at the University of Pennsylvania Medical School and joined Harvard Medical School and Beth Israel Deaconess Medical Center as an assistant professor of medicine in 1997, and in 2006 became a full professor and Chief of the Division of Matrix Biology. In 2013, Dr. Kalluri moved to The University of Texas MD Anderson Cancer Center as the Chairman and Professor of the Department of Cancer Biology and the Director of the Metastasis Research Center and serves as the RE Bob Smith Distinguished Chair in Cancer Research. Dr. Kalluri's laboratory is focused on studies related to cancer biology and metastasis, tumor microenvironment, tissue injury/regeneration, and exosomes biology.
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- Professor, Biology of Non - Coding RNA, Institute of Molecular Biology, Mainz, Germany
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- Family Associate Professor, Laboratory of Chemical Biology and Microbial Pathogenesis, the Rockefeller University, New York NY, USA
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- Professor, Department of Cell, Developmental & Regenerative
Professor, Department of Cell, Developmental & Regenerative Biology; Black Family Stem Cell Institute; Tisch Cancer Institute; Icahn School of Medicine at Mount Sinai, New York NY, USA
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- Principal Investigator, Center for Cancer Biology, KUL - VIB, Leuven, Belgium Assistant Professor, Department of Oncology, KU Leuven, Belgium
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- Assistant Professor, Department of Biology, Stanford University, Stanford CA, USA
In the Dixon lab we have broad interests in the regulation of non-apoptotic and apoptotic cell death. In particular, we want to understand how the perturbation of intracellular metabolism leads or contributes to different forms of cell death. This work may have important clinical applications if we can find new drugs that can activate or inhibit different forms of cell death in a way that is helpful to treat diseases such as cancer (insufficient cell death) or neurodegeneration (too much cell death). We also have a strong interest in developing new technologies to monitor and quantify cell death.
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- Investigator, Institute of Neuroscience and CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China
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- Associate Professor, Department of Pathology, University of California, San Diego CA, USA
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- Professor, Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India
Cerebral cortex and the amygdala are the two most complex brain structures. The cortex is responsible for higher brain functions- perception, language, learning, memory; the amygdala is the "emotion center" of the brain. The broad interests of Shubha Tole's group are the genetic and epigenetic mechanisms that control the formation of these highly specialized structures. The group uses "knockout" and transgenic approaches, in-utero and tissue culture perturbation techniques, ChIP-seq and Mass spectrometry, neurocircuitry tracing and CLARITY-based approaches, and behavioral paradigms to pursue these questions.
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- Associate Professor of Surgery, Harvard Medical School Assistant Molecular Biologist, Center for Cancer Research Massachusetts General Hospital, Boston MA, USA
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- Associate Professor, Virginia Tech, Department of Biological Sciences, Biocomplexity Institute, Blacksburg VA, USA
Silke's group is intrigued by the question how cellular networks are wired to control cellular processes reliably, and with perfect timing and accuracy. The lab focuses on chromosome segregation and cell division, core processes of life whose proper execution is essential. To understand the underlying networks, they combine quantitative live cell imaging, yeast molecular genetics, biochemical methods and computational modeling.
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- Assistant Professor, Institute of Science and Technology Austria, Klosterneuburg, Austria
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- Associate Professor, Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland
The lab of Sophie Martin studies the spatial organisation of cells. Cell polarisation is a fundamental property that underlies many cellular functions, such as polarised growth, cell division or cell-cell fusion. Using a simple eukaryotic organism, the fission yeast Schiozsaccharomyces pombe, her recent work has focused on the regulation of a central regulator of cell polarity, the small GTPase Cdc42, and how cell polarisation culminates in cell-cell fusion during sexual reproduction.
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- Professor, School of Biosciences, University of Melbourne, Melbourne, Australia
The Persson lab aims at understanding how plants produce their cell walls, with a particular focus on the prominent cell wall polymer cellulose. This is the major contributor to the biomass of a typical plant and consists of glucan chains that are hydrogen-bonded into microfibrils, which also provide the major strength to the cell wall. Cellulose is produced at the plasma membrane by large multimeric cellulose synthase (CESA) complexes. A major goal of the group is to understand how the CESA complex is regulated, what the components involved in making cellulose are, how the cytoskeleton impacts cellulose synthesis and the means that the cell wall uses to communicate with the interior of the cell.
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- Professor Department of Molecular and Cellular Biology, Harvard University, Cambridge MA, USA Biozentrum, University of Basel, Basel, Switzerland
The Mango lab studies embryonic development, developmental plasticity and chromatin organization using the C. elegans. Her lab has probed the earliest stages of embryogenesis, when embryonic cells transition from developmental plasticity to specification of cell fates. Her work has focused on the master regulators that specify organ fate and on the dynamic nuclear architecture within developing embryos. More recently, her lab has shown that developmental processes in the embryo are modulated by the environment experienced by the parent. The Mango lab is fascinated by this observation, which suggests embryogenesis is sensitive to cross-generational signaling. The lab uses a combination of genomics, genetics and cell biology to identify key regulators and understand how they function.
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- Professor, Department of Biomedicine, Aarhus University, Aarhus, Denmark
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- Associate Professor, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden
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- Professor, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
The laboratory of Tatsushi Igaki explores how cells communicate with each other to establish and maintain multicellular systems, using Drosophila as a model organism. His research focuses on understanding epithelial cell-cell communications such as cell competition and cooperation, which govern tissue growth, homeostasis, aging, and cancer.
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- Distinguished Professor, Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill NC, USA
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- Professor of Physics and Genomics, Princeton University, Princeton NJ, USA
Director, Evelyn F. and William L. McKnight Brain Institute; Director, 1Florida Alzheimer's Disease Research Center; Member, Center for Translational Research in Neurodegenerative Disease; Professor, Department of Neuroscience, College of Medicine, University of Florida, Gainesville FL, USA
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- Junior Investigator and Core Member, New York Genome Center Assistant Professor, Department of Systems Biology, Columbia University, New York NY, USA
Tuuli Lappalainen is a human geneticist whose research focuses on functional genetic variation in human populations and its contribution to human traits and diseases. Her lab develops approaches for integrating large-scale genome and transcriptome sequencing data to understand how genetic variation affects gene expression, which gives insight to biological mechanisms underlying genetic risk to disease. She has participated in many genomics consortia such as the Genotype Tissue Expression (GTEx) Project, TOPMed, 1000 Genomes, and the Geuvadis Consortium.
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- Professor, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland / Nuclear Envelope, Mitosis, Ribosome Synthesis
Research in the Kutay lab is centered on nuclear biology of mammalian cells. One main research focus is the structure, function and dynamics of the nuclear envelope, giving emphasis on the biogenesis of nuclear envelope constituents and the molecular mechanisms that drive the disintegration of the nuclear compartment at the onset of open mitosis. A second line of research seeks to decipher the highly regulated and mechanistically unique processes responsible for the production of ribosomal subunits, exploiting biochemical, high-content screening and proteomic approaches.
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- Professor, Harvard University, Department of Molecular and Cellular Biology, Cambridge MA, USA
Chair Professor, Department of Biology, Southern University of Science and Technology; Medi-X Institute, SUSTech Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, Guangdong, China
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- Professor Wellcome Trust Senior Research Fellow MRC Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK
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- Associate Professor, Baylor College of Medicine, Houston TX, USA
Dr. Zhang's research focuses on breast cancer metastasis and tumor immunology. In the former area, he is interested in elucidating mechanisms underlying the early-stage bone colonization of disseminated tumor cells and novel therapeutic strategies to eliminate latent breast cancer cells. In the latter, he concentrates on characterizing the aberrant immunosuppressive cells with respect to heterogeneity, cellular plasticity, cell-of-origin, and impact on immunotherapies.
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- Professor, HHMI - GBMF Investigator, Department of Botany and Plant Sciences, University of California, Riverside CA, USA
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- Professor, Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
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- Professor, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
Yi Arial Zeng is interested to reveal the identity of adult stem cells in various tissues, understand their regulatory mechanisms, determine how these mechanisms have been hijacked in diseases, and learn how to manipulate the key players for the purposes of regenerative and cancer medicine. She has focused her research efforts on mammary stem cells and breast cancers.
Dr. Wang's research mainly focuses on genetic and molecular mechanisms of heart failure and metabolic disorders. His lab discovered important stress-signaling mechanisms in the pathogenesis of heart failure and revealed functional importance of amino acids catabolism in heart failure and metabolic disorders. His lab reported novel regulatory mechanisms in cardiac transcriptome reprogramming involving RNA splicing regulation and non-coding RNA mediated epigenetic modulation. In addition, Dr. Wang's lab employed a systems genetic approach to discover novel players in cardiovascular physiology and pathology.
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- Professor, the University of Tokyo, Tokyo, Japan
Yukiko Gotoh's research goal is to understand the molecular basis of brain development with an emphasis on the regulation of neuralstem/progenitor cell fate and epigenetics. Her group also aims at understanding the signal transduction pathways that regulate cell proliferation, death/survival, differentiation and immune responses and the involvement of these pathways in neurological disorders.