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Whether the product is being applied under the tongue, smoked, used in a tea, vaped, or used as a food... You may then 'dial it back' until you find the smallest dose that does what you wish. Much research indicates that cancers respond in 'dose dependent fashion', suggesting that building up to larger doses may be more beneficial... Oils applied under the tongue can be expected to have an effect with 0-90 minutes. Due to its umbilical nerve endings, the belly button is also another possible site of application. Start with one or two drops morning and night, and gradually increase by a couple of drops every three to five days; or as directed by your physician.