CYSTIC FIBROSIS ANIMAL MODELS CORE

This website is intended to serve as a resource about existing animal models of cystic fibrosis that are available to the research community. Although this site is not intended to contain all existing information about every single CF animal model published, this site aims to give a general overview of the CF animal models, provide links to suggested literature, and provide contact information for laboratories and cores that can assist in obtaining each CF animal model... Pigs share many similarities to humans including body size, anatomical features, and physiology... Cystic Fibrosis (CF) is a mono-genetic disease caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). Although the disease results in many manifestations, it is consistently characterized by chronic lung infection, poor growth, exocrine pancreatic insufficiency, intestinal obstruction and malabsorption, reduced fertility, and shortened lifespan. Understanding this multi-systemic disease..