XIAO-OU ZHANG LAB

Our lab is dedicated to delving into the intricacies of RNA processing, a critical process that significantly impacts the diversity of gene expression in living organisms. Phenotypic variations in humans arise from nuanced changes in gene regulation, resulting in a wide array of gene expression patterns from the same genetic code. Recent research has provided unprecedented insights into the individual molecular mechanisms orchestrating shifts in mRNA levels, revealing that the remarkable diversity of the transcriptome stems from distinct ways RNA molecules are processed.While conventional gene expression studies often concentrate on fixed RNA levels, living systems inherently possess dynamism. This leads us to a fundamental question in functional genomics: How do the myriad dynamic molecular processes converge to shape the cellular RNA landscape? Our mission is to understand the velocity and efficiency of pivotal milestones in the RNA life cycle: the elongation phase during..

Also known as: Xiao-Ou Zhang Lab (Tongji University)