JOSEPH

To address these and other questions, we design computer simulations and develop theoretical approaches that enable us to interrogate intracellular compartments across a variety of spatiotemporal scales. Specifically, we integrate molecular dynamics and Monte Carlo-based techniques, as well as implement and design atomistic, coarse-grained, and minimal model representations of biomolecules. Using these tools, we investigate the factors that govern the formation, dissolution, and misregulation of biomolecular condensates. We then exploit the mechanistic insight to rationally design condensates with novel functions... Welcome to the Joseph Group at Princeton. We are part of the Department of Chemical and Biological Engineering and the Princeton Bioengineering Initiative.

Also known as: Joseph Group