The Lewis Hotel is a historic building located in Cherokee, Iowa, United States. Robert A. Lewis was a New York City native who settled in the Cherokee area in 1872. He had a background in carpentry, but he established a nursery in Cherokee. After moving into town he started planning for his hotel around 1897. He served as the contractor for its construction, and it was completed two years later. The hotel remained in the care of his family until 1966...
The former hotel building was individually listed on the National Register of Historic Places in 1997. It was included as a contributing property in the Cherokee Commercial Historic District in 2005.