SHI LAB

Our lab is captivated by the boundless potential of nanobodies, and we have developed powerful proteomic technologies to deconstruct the diverse array of serum-circulating nanobodies. By using this approach, we can uncover thousands of highly specific and multiepitope nanobodies, often with unprecedented affinity, that can be harnessed for drug development. For instance, we have recently generated a vast repertoire of broad-spectrum ultrapotent nanobodies against SARS-CoV-2 and other SARS-like viruses, which can be used to fight against the current pandemics and future outbreaks. By collaborating with structural biologists and modellers, we are investigating the structural basis of ultrahigh-affinity nanobody binding to disease targets... We are a team of passionate scientists, committed to pushing the boundaries of biomedical sciences. Our aim is to develop proteomic techniques that will revolutionize the way we discover, create and engineer biomolecules with therapeutic potentials...

Also known as: Shi Lab Icahn School of Medicine at Mount Sinai

Primary location: New York United States