PSDL

Work in the PSDL is funded by the National Institutes of Health, many Batten disease foundations and our industrial partners... The Pediatric Storage Disorders Lab (PSDL), led by Jonathan D. Cooper, PhD, is the leading international center for the morphological analysis of pathological changes in neuronal ceroid lipofuscinoses (NCL) or Batten disease. We have been investigating which parts of the central nervous system are affected. We also research how different cell types are impacted by disease in mouse models of NCL and in a series of naturally occurring or engineered sheep and dog models. We use this information about NCL disease biology to better target experimental therapies to where they can be most effective... In addition to pathology, the lab uses a broad range of techniques, including mouse behavior, primary neuron and glial cultures, biochemical and molecular analyses, in addition to enzyme replacement, gene therapy and small molecule approaches. Our work focuses mostly..

Also known as: Pediatric Storage Disorders Lab, Washington University in St. Louis

Primary location: Louis United States