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  • lifesensors.com
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Our goal at LifeSensors is to assist your research related to the complex and diverse Ubiquitin Proteasome System. We properly leverage our ubiquitin products, TUBE technologies, and SUMO-fusion systems to help you discover and develop targeted drugs..
Relevance: 21.855461
  • www.ubiquitin.at
addresses the mechanism of signaling proteins that are under control of various ubiquitin-like modifiers. To this end, groups within the VBC Ubiquitin Club study fundamentally important biological processes focused on .....
Relevance: 20.62012
  • www.ub-friends.at
addresses the mechanism of signaling proteins that are under control of various ubiquitin-like modifiers. To this end, groups within the VBC Ubiquitin Club study fundamentally important biological processes focused on .....
Relevance: 20.460777
  • www.binninglab.com
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The Binning lab studies how oncoviruses such as Human Papillomavirus (HPV) re-wire host ubiquitin machinery to support viral replication and drive tumorigenesis. By exploring the link between human disease states and dysregulation of ubiquitin..
Relevance: 19.419353
  • www.ubpbio.com
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The Ubiquitin-Proteasome Biotechnologies (UBPBio), LLC is a privately owned company, established by scientists and investors in 2011. UBPBio is dedicated to providing the academic and industrial communities with high quality reagents to accelerate..
Relevance: 19.236944
  • progenra.com
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Progenra is Dedicated to Finding New Medicines Through Targeting the Ubiquitin Proteasome System to fill unmet needs in a spectrum of therapeutic areas... Progenra's mission is to leverage its expertise in the ubiquitin proteasome system, Molecular..
Relevance: 19.004215
  • cost-proteostasis.eu
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The COST Action PROTEOSTASIS BM1307 is an European network with members from almost all countries in Europe. Its main objective is to facilitate research and collaborations in the fields of Ubiquitin/Proteasome, Ubiquitin-likes, autophagy and..
Relevance: 17.87161
  • stieglitz-lab.com
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We use structural and biophysical techniques to elucidate the mechanism of ubiquitination in infection and immunity. Subversion of the NFkB pathway by IpaH ligases from Shigella. Activation of the NFkB pathway involves different ubiquitin ligases..
Relevance: 17.771639
  • mdm2signaling.com
Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor...
Relevance: 17.619474
  • www.mabblab.org
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It is estimated that there are 500 - 1,000 human ubiquitin E3s, some of which are disrupted in human neurological disorders. We are interested in developing novel approaches for the identification of E3 ubiquitin ligase substates in neural tissues...
Relevance: 17.58745
  • www.agbiopro.com
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Over the last 15 years, we have accumulated invaluable specific experience in drug discovery in the ubiquitin-proteasome system. Our work includes diverse modalities such as Degraders, GLUTACs, E3 binders, E3 inhibitors, small molecules, combination..
Relevance: 17.577593
  • ebennettlab.com
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In the Bennett lab, our research is focused on understanding how the proteome is dynamically remodeled in response to cellular stress. In particular, we study mechanisms employed by the cell's protein degradation system to buffer the cell against..
Relevance: 17.34512
  • www.baatral.com
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Proteolysis targeting chimeric (PROTAC) technology is an effective endogenous protein degradation tool developed in recent years that can ubiquitinate the target proteins through the ubiquitin-proteasome system (UPS) to achieve an effect on tumor..
Relevance: 16.959099
  • www.ubience.com
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UBIENCE is a biopharmaceutical company whose mission is to improve the quality of life for patients by researching, developing and commercializing treatments for diseases associated with abnormalities in the ubiquitin-proteasome system...
Relevance: 16.826534
  • toczyskilab.ucsf.edu
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Our laboratory has two major focuses, the cell cycle and ubiquitin-mediated proteolysis. In both cases, we do a mix of biochemistry, genetics, and cell biology using both yeast and mammalian cells...
Relevance: 16.744066
  • www.timmslab.com
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We are a research team at the University of Cambridge, based on the Cambridge Biomedical Campus. We seek to develop and exploit genetic technologies to... We employ expression screening approaches to explore how E3 ubiquitin ligases selectively..
Relevance: 16.028175
  • www.southbaybio.com
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We are specialists in assay development and the Ubiquitin Proteasome System. We create novel screening technologies... We offer human immuno and constituative 20S proteasome. We also offer several fluorecent substrates specific for immuno or..
Relevance: 15.896941
  • www.hokuto-oto.info
21) Katayama A, Ogino T, Bandoh N, Takahara M, Kishibe K, Nonaka S, Harabuchi Y: Overexpression of small ubiquitin-related modifier-1 and sumoylated Mdm2 in oral squamous cell carcinoma: possible involvement in tumor proliferation and prognosis. Int..
Relevance: 15.585827
  • www.hoppelab.uni-koeln.de
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The Hoppe lab - Proteostasis in Development and Aging... A combination of genetic, biochemical and in vivo imaging techniques allows us to examine the dynamic cross talk between folding and degradation networks by focusing on the prominent muscle..
Relevance: 15.581466
  • www.gileslab.com
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The Wang and Giles Labs have worked together to study the roles of ubiquitin-specific proteases (USP16 and USP49) in regulating gene expression, chromatin structure, and pluripotentcy... Lab of Dr. Keith E Giles at the University of Alabama at..
Relevance: 15.201623
  • ubiquitylation.bio
The importance of the components of the ubiquitin conjugation and deconjugation systems is underscored by the fact that their deregulation has been linked to the pathogenesis of a number of human diseases, such as cancer, and neurodegenerative,..
Relevance: 14.794988
  • www.endotarget.com
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Endotarget is developing novel small molecule therapeutics that harness the body's own natural protein disposal system (the ubiquitin proteasome system) to selectively and efficiently degrade and remove disease-causing proteins. We focus on high..
Relevance: 14.5101795
  • www.bio-techne.com
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Bio-Techne empowers researchers in Life Science and Clinical Diagnostics by providing high-quality reagents, instruments, custom manufacturing, and testing services. Our family of brands creates a unique portfolio of products and services... We also..
Relevance: 14.135302
  • www.seedtherapeutics.com
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Seed Therapeutics is a global research company uniquely focused on harnessing and engineering molecules that use Molecular Glues to attack protein targets previously believed to be "undruggable."... Collaborating with an unparalleled team of world-..
Relevance: 14.131905
  • www.philpotlab.org
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UNC Neuroscience Center, an innovative, collaborative, and translational interdepartmental research center... A severe genetic disorder caused by mutations or deletions of the maternally inherited UBE3A gene. UBE3A encodes an E3 ubiquitin ligase..
Relevance: 13.9527235
  • mochrielab.yale.edu
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We apply physical techniques to study biological interactions. Currently our primary approach is optical tweezers where we apply a variety of techniques, including tethered particle motion, flow-forces, magnetic tweezers, and single-molecule..
Relevance: 13.913765
  • www.protein-degradation.org
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A third major focus of our research program is how the degradation systems can be reprogrammed to induce the degradation of otherwise stable and harmful proteins by using small molecules. Reprogramming approaches have great promises in the treatment..
Relevance: 13.141699
  • www.ethrifty.ca
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The "Enhanced-Thifty" or E-Thrifty is a chemcial shift-based threading method, which uses sequence and chemical shift similarity as well as chemical shift-derived secondary structure, super-secondary structure and accessible surface area to identify..
Relevance: 12.986371
  • weihllab.wustl.edu
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Our goal is to understand the molecular mechanisms of protein inclusion formation, disaggregation and clearance in myodegenerative and neurodegenerative diseases... We believe that dysfunction in protein quality control (molecular chaperones) and..
Relevance: 12.881174
  • www.ubiquigent.com
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As pioneers in the rapidly emerging deubiquitinase (DUB) space, Ubiquigent™ is uniquely positioned to drive forward the discovery and development of novel DUB inhibitors, DUB-targeting Proteolysis Targeting Chimeras (PROTACs) and DUB-targeting..
Relevance: 12.164453