APC RESISTANCE

Plasma is incubated with the APTT reagent for a standard period of time. Coagulation is initiated by the addition of CaCl 2 in the absence and presence of APC and the time for clot formation is recorded... An APTT-based assay for the detection of the APC resistance phenotype, i.e. the poor anticoagulant response to activated protein C (APC). The test result (APC ratio) gives an estimation of the anticoagulant function in vivo and provides information on the thrombotic risk associated with inherited and acquired APC resistance. Detects the APC resistance phenotype regardless of its cause. Detects both inherited and acquired APC resistance... APC RESISTANCE UNIVERSITY Introduction | Biochemistry | Clinical Aspects | Key Reports | PubMed Abstracts | References | Assay Methods | APC Resistance Phenotyping | Factor V Mutation Screening | FAQ ABOUT ACTIVATED PROTEIN C RESISTANCE During the last years, publications have suggested that the APC resistance phenotype is a risk factor for venous..